Rosuvastatin treatment improves arterial stiffness with lowering blood pressure in healthy hypercholesterolemic patients

Oh, Pyung Chun; Han, Seung Hwan; Koh, Kwang Kon; Lee, Kyounghoon; Seo, Jong Goo; Suh, Soon Yong; Ahn, Taehoon; Choi, In Suck; Shin, Eak Kyun

doi:10.1016/j.ijcard.2014.07.181

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…The influence of glucose metabolism on haemodynamics was taken into consideration in the regression analyses by the inclusion of the QUICKI index in the variables. Many reports support the view that statins can improve arterial stiffness [19,20,24]. The present results raise the possibility that the lowering effect of statins on PWV could partially be mediated via the beneficial effect on central BP.…”

Section: Discussionsupporting

confidence: 83%

“…In a study comprising 20,074 subjects, the incidence of new onset of hypertension was lower in subjects with lower LDL-C [13]. Several studies have revealed small but significant reductions in BP after treatment with statins [18,19,22,23]. A meta-analysis comprising 828 subjects reported a decrease of BP by 1.9/0.9 mmHg following statin therapy that was unrelated to age, changes in serum cholesterol, or length of the trial [21].…”

Section: Discussionmentioning

confidence: 99%

“…LDL-C can reduce nitric oxide bioavailability and blunt the vasodilator response to acetylcholine [4,[14][15][16][17], and the resulting endothelial dysfunction could be manifested as increased BP. Following treatment with statins, several trials have shown moderate but statistically significant lowering effect on BP [18][19][20][21][22][23], reduction of arterial stiffness [19,20,24], and improved endothelial function [25,26].…”

Section: Introductionmentioning

confidence: 99%

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LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs

et al. 2018

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Background and aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects. Methods: We recruited 615 volunteers (19-72 years) without lipid-lowering and BP-lowering medication. Supine haemodynamics were recorded using continuous radial pulse wave analysis, wholebody impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables. Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m 2 , office BP 141/89 (21/13) mmHg, creatinine 74 (14) µmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p<0.05 for all). When central BP was included in the model for PWV, LDL-C was no longer an explanatory factor for PWV. Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs

et al. 2018

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“…Interestingly, previous authors showed that rosuvastatin treatment significantly reduced arterial stiffness by lowering both blood pressure and LDL-C in hypercholesterolemic subjects. 4 These findings may suggest a previously unexplored pathophysiological link between LDL-C and blood pressure.…”

mentioning

confidence: 87%

“…Our data have been properly interpreted and our conclusions are supported by much emerging evidence from other studies. [2][3][4][5] Those in our cohort of 597 COVID-19 inpatients were diagnosed and had lipid profiles taken at the time of admission. Patients were categorized according to the stage of disease course based on symptomatic severity.…”

mentioning

confidence: 99%

Misinterpreting data in lipidology in the era of COVID-19

Fogacci

Borghi

Cicero

2020

Journal of Clinical Lipidology

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Association of arterial stiffness with cognition in patients with Lewy body disorder

et al. 2017

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The brachial-ankle pulse wave velocity (baPWV) is a marker for arterial stiffness, which is associated with cardiovascular diseases. Arterial stiffness is associated with cognitive function in the elderly and patients with Alzheimer's disease (AD). We aimed to investigate the association between arterial stiffness and cognitive function in patients with Lewy body disorder (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We consecutively included 123 patients with PD, 10 patients with DLB, and 27 AD controls. Patients with PD were divided into three groups of normal cognition (PD-NC, n = 63), mild cognitive impairment (PD-MCI, n = 43), and dementia (PD-D, n = 17). Arterial stiffness, measured as baPWV, was compared between the PD-NC, PD-MCI, PD-D, DLB, and AD patients. In LBD, we analyzed the association between arterial stiffness and each cognitive domain with adjustment for covariates. Higher baPWV was significantly associated with cognitive decline in patients with LBD (baPWV in PD-D > PD-MCI > PD-NC; DLB > PD-NC). There was no significant difference in baPWV between PD-D, DLB, and AD patients. In LBD patients, higher baPWV was associated with lower mini mental state examination score (β ± SE = -0.003 ± 0.001, p = 0.007) and more severe dementia. Higher baPWV was also associated with lower performance in attention, language, visuospatial function, memory, and executive function in LBD patients. This suggests that vascular brain injury is associated with cognitive dysfunction in LBD.

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Rosuvastatin treatment improves arterial stiffness with lowering blood pressure in healthy hypercholesterolemic patients

Cited by 13 publications

References 24 publications

LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs

LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs

Misinterpreting data in lipidology in the era of COVID-19

Association of arterial stiffness with cognition in patients with Lewy body disorder

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