Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

“…The majorities of these studies involved two tests that are used to model antidepressant like effects in mice-the Tail Suspension Test (TST) and Forced Swimming Test (FST). The administration of rosemary continuously decreased the immobility time of mice in both the TST and the FST, indicating an antidepressantlike effect [31][32][33][34]. Rosemary's antidepressant potential was further bolstered when it was found to decrease exploratory and anhedonic-like behavior in bulbectomized mice [35].…”

“…Rosemary is believed to enhance dopaminergic, serotonergic, noradrenergic, and cholinergic functions within the brain, possibly explaining its antidepressant effects [31][32][33]. Rosemary has also been found to increase the concentration of neurotransmitters in the brains of mice [33]. Several compounds in rosemary extract and essential oil are responsible for its antidepressant activity, including carnosol, betulinic acid, ursolic acid, and polyphenols [31,33,34].…”

“…Rosemary has also been found to increase the concentration of neurotransmitters in the brains of mice [33]. Several compounds in rosemary extract and essential oil are responsible for its antidepressant activity, including carnosol, betulinic acid, ursolic acid, and polyphenols [31,33,34].…”

“…There is much evidence that the antidepressant activity of R. officinalis depends on interactions with the monoaminergic system. Rosemary is believed to enhance dopaminergic, serotonergic, noradrenergic, and cholinergic functions within the brain, possibly explaining its antidepressant effects [31][32][33]. Rosemary has also been found to increase the concentration of neurotransmitters in the brains of mice [33].…”

A review on antidepressant effect of medicinal plants

“…Proteomic analysis of PC12 cells demonstrated that R. officinalis caused upregulation of tyrosine hydroxylase and pyruvate carboxylase (the genes involved in gabaergic, serotonergic and dopaminergic systems). R. officinalis polyphenols also protected nerve cells against corticosterone -induced toxicity (Sasaki et al, 2013).…”