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Cited by 11 publications
(7 citation statements)
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References 74 publications
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“…Then, RA would be classified in Category 5 according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals (United Nations, 2017), in which substances with LD 50 ranging from 2,000 to 5,000 mg/kg (p.o.) are taken as having low toxicity (do Nascimento et al, 2020). Furthermore, during the development process of new drugs with therapeutic or preventive action, an essential discussing point is the dose translational between distinct animal species.…”
Section: Discussionmentioning
confidence: 99%
“…Then, RA would be classified in Category 5 according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals (United Nations, 2017), in which substances with LD 50 ranging from 2,000 to 5,000 mg/kg (p.o.) are taken as having low toxicity (do Nascimento et al, 2020). Furthermore, during the development process of new drugs with therapeutic or preventive action, an essential discussing point is the dose translational between distinct animal species.…”
Section: Discussionmentioning
confidence: 99%
“…Many natural derived immunomodulating components such as flavonoid, polysaccharide, polyphenols, phycocyanin, and probiotics have been widely reported to exert anti-allergic activity on OVA-induced intestinal food allergy [ 21 , 22 ]. The immunomodulatory impacts of RA also make it a novel potential agent for the treatment of immune disorders of the body [ 23 ]. In allergic rhinitis, dermatitis, and asthma, RA showed obvious beneficial effects in alleviating allergic reactions such as mild anaphylactic symptoms, reduction in specific IgE and immune-mediators, and relieved tissue damage [ 24 , 25 , 26 ].…”
Section: Discussionmentioning
confidence: 99%
“…Few exciting research studies presented the gastro-protective effects of RA in ethanol-induced gastric lesions in vitro and in animal models. RA combated ulcer formation through modulation of oxidative parameters and inflammatory markers (do Nascimento et al 2020 ; Wang et al 2021b ). Similar results were reported on ethanol-induced gastritis challenged rats.…”
Section: Pharmacological Properties Of Ramentioning
confidence: 99%