Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling

Zhou, Xiang; Wang, Weiming; Li, Zhaofeng; Chen, Lin; Wen, Caiyun; Ruan, Qingqing; Xu, Zheng; Liu, Rongdiao; Xu, Jinzhong; Bai, Yongheng; Deng, Jie

doi:10.1016/j.phymed.2021.153861

Cited by 15 publications

(15 citation statements)

References 36 publications

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“…Blocked FOXOM1 transcription factors, upregulated pro-apoptotic genes and exhibited anti-tumorigenic actions in triple negative breast cancer cells iv. Reduced pancreatic ductal adenocarcinoma via G1/S cycle arrest and inhibition of Gli translocation in mouse model of PDAC v. Propitiated TLR4/NF-κB/STAT3 activation and reduced colitis induced colon cancer in murine model Jang et al ( 2018 ) Wang et al ( 2019 ) Messeha et al ( 2020 ) Zhou et al ( 2022 ) Jin et al ( 2021a ) 21 Anti-diabetic i. Exhibited protective role via anti-inflammatory action in diabetic cerebral ischemic damage ii.…”

Section: Clinical Implications Of Ramentioning

confidence: 99%

“…RA significantly suppressed NF-κB, VEGF, TNF-α expression and restored P53, Bcl-2, Bax, and caspase-3 levels, causing apoptosis (Mahmoud et al 2021 ). Interestingly, in another study, Zhou et al ( 2022 ) reported RA-based reduction in pancreatic ductal adenocarcinoma by restraining Gli translocation and facilitating proteasomal degradation. In addition, RA induced G1/S cell cycle arrest and apoptosis in the pancreatic ductal adenocarcinoma cells by regulating apoptotic genes' expression.…”

Section: Clinical Implications Of Ramentioning

confidence: 99%

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Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Section: Clinical Implications Of Ramentioning

confidence: 99%

Section: Clinical Implications Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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“…RA induced cell cycle arrest in treating multiple tumor cells, mainly through upregulation of p53 and p21 and downregulation of cyclins D1, E, and B1 [ 96 ]. RA induced G0/G1-phase arrest in breast and pancreatic cancer [ 97 , 98 ]. G2/M arrest occurred in treating kidney cancer and oral cancer [ 99 , 100 ].…”

Section: Biological Processes and Mechanism Of Action Of Ra In Tumor ...mentioning

confidence: 99%

“…Cell cycle arrest represents an opportunity for cancer cells to enter apoptosis. RA increased the expression of apoptosis-related proteins, including BCL-2 associated X (BAX), caspase-3, and caspase-8, and attenuated the expression of anti-apoptotic proteins B cell lymphoma-2 (BCL-2) and poly (ADP-ribose) polymerase (PARP) [ 51 , 98 ]. The upstream mechanism of RA inducing cell cycle arrest included histone deacetylases 2 (HDAC2) and glioma-associated oncogene homolog 1 (Gli1).…”

Section: Biological Processes and Mechanism Of Action Of Ra In Tumor ...mentioning

confidence: 99%

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Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Zhao

Jin

et al. 2022

Biomolecules

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Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniques to improve RA bioavailability and provide a mechanistic discussion of RA regarding tumor prevention, treatment, and adjuvant therapy. RA exhibits anticancer activity by regulating oxidative stress, chronic inflammation, cell cycle, apoptosis, and metastasis. These data suggest that daily use of RA-enriched dietary supplements can contribute to tumor prevention and treatment. RA has the potential for application in anti-tumor drug development.

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Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis.

ŞENGELEN,

ÖNAY-UÇAR

2024

Phytomedicine

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Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling

Cited by 15 publications

References 36 publications

Biomedical features and therapeutic potential of rosmarinic acid

Biomedical features and therapeutic potential of rosmarinic acid

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis.

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