2020
DOI: 10.1038/s41598-020-73713-w
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Abstract: Plasmodium vivax is the most prevalent cause of malaria outside of Africa. P. vivax biology and pathogenesis are still poorly understood. The role of one highly occurring phenotype in particular where infected reticulocytes cytoadhere to noninfected normocytes, forming rosettes, remains unknown. Here, using a range of ex vivo approaches, we showed that P. vivax rosetting rates were enhanced by plasma of infected patients and that total immunoglobulin M levels correlated with rosetting frequency. Moreover, rose… Show more

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Cited by 13 publications
(18 citation statements)
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“…In fact, higher rosetting rates were recorded in the phagocytosis assay, suggesting that the parasites possess capacity of forming more rosettes. Functionally, rosetting of P. knowlesi -IRBC with URBC hampered phagocytosis of IRBC, which agreed well with earlier findings with P. falciparum and P. vivax parasites ( Albrecht et al, 2020 ; Lee et al, 2020 ). Rosetting reduced the phagocytosis of P. knowlesi -IRBC by ∼38%.…”
Section: Discussionsupporting
confidence: 91%
“…In fact, higher rosetting rates were recorded in the phagocytosis assay, suggesting that the parasites possess capacity of forming more rosettes. Functionally, rosetting of P. knowlesi -IRBC with URBC hampered phagocytosis of IRBC, which agreed well with earlier findings with P. falciparum and P. vivax parasites ( Albrecht et al, 2020 ; Lee et al, 2020 ). Rosetting reduced the phagocytosis of P. knowlesi -IRBC by ∼38%.…”
Section: Discussionsupporting
confidence: 91%
“…As recently observed in several studies, P. vivax can adhere to endothelial receptors and form rosettes in a similar fashion as P. falciparum. (36,37) However, unlike P. falciparum, PfEMP1 and RIFIN antigens are absent in P. vivax. Therefore, some other antigens must be implicated in the adhesion phenomena.…”
Section: Discussionmentioning
confidence: 99%
“…Marın-Menendez et al stated that rosetting was the cytoadherence phenotype of P. vivax infection ( 21 ). The adhesive force of infected erythrocyte by P.vivax forms a rosette as strong as P. falciparum characteristic, but the specific mechanism of rosette formation in P. vivax malaria is unestablished ( 22 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, the adhesion phenotypes regarding immunoglobulin components have not been untangled yet. The rosetting was also related to Interleukin (IL)-6, IL-10, and IgM ( 22 ). Rosetting in P. vivax infection may play an essential role in the sequestration process, which elucidates parasite subpopulation in a specific organ, induces prolonged infection by the significant protection from the host immune system, and becomes a latent infection.…”
Section: Discussionmentioning
confidence: 99%