Rosacea: I. Etiology, pathogenesis, and subtype classification

Ocular rosacea: a review

“…The characteristic facial flushing, persistent erythema and telangiectasia may be caused by altered cutaneous neurovascular homeostasis. Studies have demonstrated increased blood flow in the face and larger and more numerous vessels in the face than in other areas of the body (31) . Significantly dilated blood and lymphatic vessels were reported in all subtypes of rosacea (29) .…”

“…Microbial organisms such as Helicobacter pylori, Demodex folliculorum, Demodex brevis and Staphylococcus epidermidis have been appointed as other possible causative factors in exacerbation of the disease; however this remains a controversy (23,26,31,(38)(39)(40)(41)(42)(43) . The prevalence of H. pylori infection was found higher in patients with rosacea when compared to the general population, and its eradication has been shown to influence the clinical outcome of this disease (31,39,(44)(45)(46) .…”

“…The prevalence of H. pylori infection was found higher in patients with rosacea when compared to the general population, and its eradication has been shown to influence the clinical outcome of this disease (31,39,(44)(45)(46) . However, other studies have not found such difference (41,(47)(48)(49) .…”

“…The severity of ocular rosacea symptoms is often not related to the severity of cutaneous manifestations (15,31,51,60,61) . One study found a significant relationship between ocular involvement and the severity of telangiectasia (62) .…”

Trends in the Frequency of Original Research in Acne Vulgaris, Rosacea, Dermatitis, Psoriasis, Skin Cancer, and Skin Infections, 1970–2010

“…6,7 This trend may stem from the relatively benign nature of these diseases as well as the numerous treatment modalities that have proved successful over time. [8][9][10] Nevertheless, recent studies on genetic variations between Propionibacterium acnes strains, 11 a potential bacteriophage-based treatment for acne, 12 and the continual search for a microbial cause of rosacea offer an exciting future for research in these topics. 13 Research into dermatitis has stayed relatively stable since 1970, especially in recent years.…”