ROS responsive mesoporous silica nanoparticles for smart drug delivery: A review

Daund, Varsha; Chalke, Siddhi; Sherje, Atul P.; Kale, Pravin Popatrao

doi:10.1016/j.jddst.2021.102599

Cited by 23 publications

(13 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enhanced concentration has been used as a stimulus for drug delivery by chemically linking molecules with disulfide bonds, and thus develops easily manipulated GSH-responsive structures. Very recently, Daund et al [153] published a review on ROS responsive NPs for smart drug delivery. Jiao et al [154] used hollow mesoporous silica nanoparticles (MS NPs) as the drug vehicle to develop the redox and pH dual stimuli-responsive delivery system, in which the chitosan was grafted on the surface of MS NPs via the cleavable disulfide bonds.…”

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

View full text Add to dashboard Cite

Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

show abstract

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

View full text Add to dashboard Cite

show abstract

“…Incorporating alternative linkers that are reactive oxygen species-responsive, such as polyproline, boronic ester, and selenium/tellurium, is an option in addition to sulfur-containing linkages. “Oxidative stress” results from a rise in ROS concentration that makes antioxidants (such as catalase or superoxide dismutase) inefficient at reducing it [ 153 ].…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

View full text Add to dashboard Cite

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

show abstract

“…The higher potency of FBZ-MCM-BLG nanoparticles to produce higher amounts of intracellular ROS concentration, when compared to that of FBZ-MCM nanoparticles, could be attributed to the pattern of drug release (drug release over a longer period of time) and the high cellular uptake efficiency of FBZ-MCM-BLG nanoparticles. Previous studies [39,40] have demonstrated that MSNs by themselves cause an increase in the production of intracellular ROS, whereas some other researchers [41] have shown that MSNs can be used as a drug carrier to remove intracellular ROS.…”

Section: Reactive Oxygen Species (Ros) Assaymentioning

confidence: 99%

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

et al. 2022

View full text Add to dashboard Cite

The clinical utilization of fenbendazole (FBZ) as a potential anticancer drug has been limited due to its low water solubility, which causes its low bioavailability. The development of a drug nanoformulation that includes the solubilizing agent as a drug carrier can improve solubility and bioavailability. In this study, Mobil Composition of Matter Number 48 (MCM-48) nanoparticles were synthesized and functionalized with succinylated β-lactoglobulin (BLG) to prevent early-burst drug release. The BLG-modified amine-functionalized MCM-48 (MCM-BLG) nanoparticles were loaded with FBZ to produce the drug nanoformulation (FBZ-MCM-BLG) and improved the water solubility and, consequently, its anticancer effects against human prostate cancer PC-3 cells. The prepared FBZ-MCM-BLG was characterized in terms of size, zeta potential, drug loading capacity, morphology, thermal and chemical analyses, drug release, cellular uptake, cell viability, cell proliferation, production of reactive oxygen species (ROS), and cell migration. The results demonstrated that the FBZ-MCM-BLG nanoparticles have a spherical morphology with a size and zeta potential of 369 ± 28 nm and 28 ± 0.4 mV, respectively. The drug loading efficiency of the new nanoformulation was 19%. The release of FBZ was pH-dependent; a maximum cumulative release of about 76 and 62% in 12 h and a burst release of 53 and 38% in the first 0.5 h was observed at pH 1.2 and 6.8, respectively. The prepared FBZ-MCM-BLG formulation demonstrated higher cytotoxicity effects against PC-3 cells by 5.6- and 1.8-fold, respectively, when compared to FBZ and FBZ-MCM nanoparticles. The new formulation also increased the production of ROS by 1.6- and 1.2-fold and inhibited the migration of PC-3 cells when compared to the FBZ and FBZ-MCM nanoparticles, respectively. Overall, FBZ-MCM-BLG nanoparticles improved FBZ delivery to PC-3 cells and have the potential to be evaluated for the treatment of prostate cancer following a comprehensive in vivo study.

show abstract

ROS responsive mesoporous silica nanoparticles for smart drug delivery: A review

Cited by 23 publications

References 128 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

Contact Info

Product

Resources

About