ROS-dependent signal transduction

Reczek, Colleen R.; Chandel, Navdeep S.

doi:10.1016/j.ceb.2014.09.010

Cited by 723 publications

(543 citation statements)

References 34 publications

Supporting

Mentioning

504

Contrasting

Unclassified

Order By: Relevance

“…It is important to mention once more that ROS are no longer viewed as just toxic by-products of mitochondrial respiration, but are now appreciated for their role in regulating various cellular signaling pathways [24]. Indeed, the adaptation to stressful conditions of our life is mediated via vitagene network in the body.…”

Section: Binding Metal Ions (Metal-binding Proteins) and Metal Chelatmentioning

confidence: 99%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

160

135

View full text Add to dashboard Cite

Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

show abstract

Section: Binding Metal Ions (Metal-binding Proteins) and Metal Chelatmentioning

confidence: 99%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

160

135

View full text Add to dashboard Cite

show abstract

“…The first includes an intermediate step involving the oxidation of Trx or GSH to the redox relay mechanism, and the second one likely results from the dissociation and subsequent activation of a target protein after H 2 O 2 oxidation of a scavenger enzyme (272). In addition, NO and its derivatives (S-nitrosothiols [SNO] and GSNO) are involved in signal transduction (103, 152, 276, 338).…”

Section: B From Signal Transduction To Posttranslational Modificationsmentioning

confidence: 99%

Redox Control of Skeletal Muscle Regeneration

Moal

Pialoux

Juban

et al. 2017

Antioxidants & Redox Signaling

148

120

View full text Add to dashboard Cite

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult skeletal muscle is capable of complete regeneration after injury, due to the properties of muscle stem cells (MuSCs), the satellite cells, which follow a tightly regulated myogenic program to generate both new myofibers and new MuSCs for further needs. Although reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been associated with skeletal muscle physiology, their implication in the cell and molecular processes at work during muscle regeneration is more recent. This review focuses on redox regulation during skeletal muscle regeneration. An overview of the basics of ROS/RNS and antioxidant chemistry and biology occurring in skeletal muscle is first provided. Then, the comprehensive knowledge on redox regulation of MuSCs and their surrounding cell partners (macrophages, endothelial cells) during skeletal muscle regeneration is presented in normal muscle and in specific physiological (exercise-induced muscle damage, aging) and pathological (muscular dystrophies) contexts. Recent advances in the comprehension of these processes has led to the development of therapeutic assays using antioxidant supplementation, which result in inconsistent efficiency, underlying the need for new tools that are aimed at precisely deciphering and targeting ROS networks. This review should provide an overall insight of the redox regulation of skeletal muscle regeneration while highlighting the limits of the use of nonspecific antioxidants to improve muscle function. Antioxid. Redox Signal. 27, 276-310.

show abstract

“…It has since become apparent that ROS also serve as signal molecules to regulate various biological processes, such as cell proliferation, differentiation, inflammation and regeneration (Finkel, 2011;Reczek and Chandel, 2015;Schieber and Chandel, 2014). The classic oxidative stress theory has been a broadly accepted explanation for aging and is the theoretical backbone for using antioxidants, such as vitamins and N-acetyl cysteine (NAC), as anti-aging supplements.…”

Section: Introductionmentioning

confidence: 99%

“…Recent reports suggested that ROS from mitochondria, known as mtROS, extend lifespan (Kawagishi and Finkel, 2014;Lee et al, 2010;Reczek and Chandel, 2015;Ristow, 2014;Wang and Hekimi, 2015;Yang and Hekimi, 2010a;Yun and Finkel, 2014). Various stimuli, such as mitochondrial dysfunction, calorie restriction, acute impairment of insulin signaling, glucose restriction or absence of a germline, can release mtROS to extend lifespan (Lee et al, 2010;Schaar et al, 2015;Schulz et al, 2007;Wei and Kenyon, 2016;Xie and Roy, 2012;Yang and Hekimi, 2010a,b;Zarse et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans

Sasakura

Moribe

Nakano

et al. 2017

Journal of Cell Science

View full text Add to dashboard Cite

Reactive oxygen species (ROS), originally characterized based on their harmful effects on cells or organisms, are now recognized as important signal molecules regulating various biological processes. In particular, low levels of ROS released from mitochondria extend lifespan. Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans. A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H 2 O 2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. These ROS signals are transduced mainly by the oxidative stress transcriptional factors SKN-1 (Nrf2 or NFE2L2 in mammals) and JUN-1, and partially by DAF-16 (a FOXO protein homolog). Cell biology experiments demonstrated a similarity between the mechanisms of PQQ-induced activation of human DUOX1 and DUOX2 and that of C. elegans BLI-3, suggesting that DUOXs are potential targets of intervention for lifespan extension. We propose that low levels of ROS, fine-tuned by the peroxidase and dual oxidase system at the plasma membrane, act as second messengers to extend lifespan by the effect of hormesis.

show abstract

ROS-dependent signal transduction

Cited by 723 publications

References 34 publications

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Redox Control of Skeletal Muscle Regeneration

Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans

Contact Info

Product

Resources

About