Root-shaped antibacterial alginate sponges with enhanced hemostasis and osteogenesis for the prevention of dry socket

Wang, Danyang; Sun, Yinyin; Zhang, Dongjie; Kong, Xiaowen; Wang, Sainan; Lu, Jinglin; Liu, Fengyuan; Lu, Shulai; Qi, Hongzhao; Zhou, Qihui

doi:10.1016/j.carbpol.2022.120184

Cited by 21 publications

(13 citation statements)

References 74 publications

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“…The blood clotting index (BCI) is a quantitative metric often used to analyze blood coagulation in vitro. The lower BCI value suggests a greater ability to pro-coagulate. ,− Their clotting ability was verified by testing the BCI of the GPZ sponge, commercial gelatin sponge (GS), and chitosan hemostatic material (Celox), as shown in Figure A. BCI declined with time, indicating that the blood was gradually clotting.…”

Section: Resultsmentioning

confidence: 99%

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Du,

Bai,

Lang

et al. 2023

Biomacromolecules

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Developing a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distributed interconnected pore structure with excellent fluid absorption. It could effectively absorb the oozing blood and increase the blood concentration while stimulating platelet activation and accelerating blood coagulation. Compared to commercial hemostats, GPZ treatment significantly accelerated hemostasis in the rat liver defect model (∼0.33 min, ≥50% reduction in the hemostatic time) and in the rabbit liver defect model (∼1.02 min, ≥60% reduction in the hemostatic time). Additionally, GPZ had excellent antibacterial and antioxidant properties that effectively protected the wound from infection and excessive inflammation. In the liver regeneration model, GPZ significantly increased the rate of hepatic tissue repair and promoted rapid functional recovery without complications and adverse reactions. Overall, we designed a simple and effective biodegradable rapid hemostatic sponge with good clinical translational potential for treating lethal incompressible bleeding and promoting wound healing.

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Section: Resultsmentioning

confidence: 99%

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Du,

Bai,

Lang

et al. 2023

Biomacromolecules

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“…These hydrogels also have the ability to promote osteogenesis by upregulating alkaline phosphatase and calcium nodule formation. [ 150 ] Gu et al. [ 22a ] developed a modified collagen scaffold by cross‐linking polyphosphate with collagen ( Figure a).…”

Section: Applications Of the Hemostasis Hydrogelsmentioning

confidence: 99%

Preparation and Application of Hemostatic Hydrogels

Zhou,

Lin,

Wang

et al. 2023

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Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due to their unique properties, including biocompatibility, tunable physical characteristics, and exceptional hemostatic capabilities. In this review, a comprehensive overview of the preparation and biomedical applications of hemostatic hydrogels is provided. Particularly, hemostatic hydrogels with various materials and forms are introduced. Additionally, the applications of hemostatic hydrogels in trauma management, surgical procedures, wound care, etc. are summarized. Finally, the limitations and future prospects of hemostatic hydrogels are discussed and evaluated. This review aims to highlight the biomedical applications of hydrogels in hemorrhage management and offer insights into the development of clinically relevant hemostatic materials.

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“…Stanching bleeding requires debridement which may trigger secondary bleeding, and the hemostatic material may enter into the bloodstream to form a blood clot in the body. With continuous research on the mechanism of hemostasis, diverse new hemostatic materials attract more attention. − These materials exert hemostatic effects in terms of obstructing blood flow, concentrating blood components, and activating or accelerating clotting pathways and clot formers, which, to a certain extent, conform to clinical medical needs. − …”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Topical Hemostatic Materials

Liu,

Zhang,

Yao

et al. 2024

ACS Appl. Bio Mater.

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Untimely or improper treatment of traumatic bleeding may cause secondary injuries and even death. The traditional hemostatic modes can no longer meet requirements of coping with complicated bleeding emergencies. With scientific and technological advancements, a variety of topical hemostatic materials have been investigated involving inorganic, biological, polysaccharide, and carbonbased hemostatic materials. These materials have their respective merits and defects. In this work, the application and mechanism of the major hemostatic materials, especially some hemostatic nanomaterials with excellent adhesion, good biocompatibility, low toxicity, and high adsorption capacity, are summarized. In the future, it is the prospect to develop multifunctional hemostatic materials with hemostasis and antibacterial and anti-inflammatory properties for promoting wound healing.

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Root-shaped antibacterial alginate sponges with enhanced hemostasis and osteogenesis for the prevention of dry socket

Cited by 21 publications

References 74 publications

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Preparation and Application of Hemostatic Hydrogels

Recent Advances in Topical Hemostatic Materials

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