Room Temperature Synthesis and Characterization of Novel Bi(III) Complex with 2-Amino-3- Carbomethoxy-4,5,6,7-Tetrahydrobenzo[B]Thiophene as Potential Antimicrobial Agent

Abstract

A novel bismuth(III) complex with 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) as a ligand have been synthesized. The novel complex was characterized on the basis of its IR, NMR, elemental analysis and MS spectral data. It was found that the ligand behaves as a monodentate chelating agent and bonds to the metal ion through the nitrogen atom of the amino group to form the [Bi III (ACTT) 6 ]Cl 3 complex. The new complex compound displayed significant antimicrobial activity (MIC = 8-32 μg/mL) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, Candida albicans, Candida tropicalis and Cryptococcus neoformans.

Thiophene‐containing compounds with antimicrobial activity

“…The highest growth inhibition for the ligand derived from ethylenediamine was recorded in the case of S. flexneri, B. subtilis and T. longifusus, while S. the aforementioned thiophene acts as a monodentate ligand, presumably through the nitrogen atom of the amino group. [234] MIC values that have been determined for this complex range from 8 to 32 μg/ml against bacteria, while MIC values against three fungal strains are also 32 μg/ml. A second report [235] deals with the antimicrobial activity of the chromium complex [Cr(III)L 3 ](NO 3 ) 3 of the same aminothiophene (L), which presumably acts as a bidentate ligand coordinated to the metal ion through the nitrogen atom of the amino group and the oxygen atom of the carbonyl in the ester group.…”