Roll press design—influence of force feed systems on compaction

Roller compaction of different pseudopolymorphic forms of Theophylline: Effect on compressibility and tablet properties

“…Another advantage is that it does not require a drying stage and therefore it is suitable for compounds that either have a low melting point or degrade rapidly upon heating (Bindhumadhavan et al, 2005). Roller compaction is a continuous dry compaction process in which uniformly mixed powders are compressed between two counter rotating rolls to form compacts which are subsequently broken into granules (Guigon and Simon, 2003;Yehia, 2007). It also can be described as a particle-bonding process where the bonds within the granules are subsequently formed through particle rearrangement, deformation, fragmentation, and bonding (Miller, 1997).…”

Application of Submicron-sized Binder Particles in Dry Granulation Using a Roller Compactor and Its Evaluation

“…いた乾式造粒法が再注目されつつある [1,2] Scanning electron micrographs of APAP crystalline particles and APAP crystalline particles after pre-mixing with raw HPC or HPC-subMPs Scanning electron micrographs of APAP crystalline particles after pre-mixing with HPCsubMPs with different mass fractions of particles smaller than 1 μm: Applied amount of HPC to APAP was 10 mass% Characteristics of HPC-subMPs with different mass fractions of particles smaller than 1 μm, APAP granules prepared by roller compaction/dry granulation process and final blends of APAP granules with excipients …”

Briquetting of UBC by double roll press part I: The application and limitations of the Johanson model

“…Generally, modeling of feeding region is difficult and no simple model exists to estimate nip pressure. In the case of force feed system, it is more difficult, as the blade motion is reported to cause periodical fluctuation of pressure [13] [14]. The need to estimate nip pressure is one of the weaknesses of Johanson model.…”