2014
DOI: 10.1002/jcp.24792
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Abstract: Craniofacial bone marrow mesenchymal stem cells (BMSCs) display some site-specific properties that differ from those of BMSCs derived from the trunk and appendicular skeleton, but the characteristics of craniofacial BMSCs and the mechanisms that underlie their properties are not completely understood. Previous studies indicated that special AT-rich binding protein 2 (SATB2) may be a potential regulator of craniofacial skeletal patterning and site-specific osteogenic capacity. Here, we investigated the stemness… Show more

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Cited by 36 publications
(31 citation statements)
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“…SATB2 is a target gene of miR‐31a‐5p, which has been proven by some prior studies (Aprelikova et al., 2010; Deng, Weng et al., 2013; Deng, Zhou et al., 2013). Our previous investigation has demonstrated that SATB2, as a transcriptional regulator, functions broadly (Dong et al., 2015) and is involved in osteogenic differentiation in age‐related BMSCs (Strickland, Wasserman, Giassi, Djordjevic, & Parra‐Herran, 2016; Zhou et al., 2016). Our results from both knockdown and gain‐of‐function approaches showed that miR‐31a‐5p inhibited osteogenic differentiation by negatively regulating SATB2 expression.…”
Section: Discussionmentioning
confidence: 99%
“…SATB2 is a target gene of miR‐31a‐5p, which has been proven by some prior studies (Aprelikova et al., 2010; Deng, Weng et al., 2013; Deng, Zhou et al., 2013). Our previous investigation has demonstrated that SATB2, as a transcriptional regulator, functions broadly (Dong et al., 2015) and is involved in osteogenic differentiation in age‐related BMSCs (Strickland, Wasserman, Giassi, Djordjevic, & Parra‐Herran, 2016; Zhou et al., 2016). Our results from both knockdown and gain‐of‐function approaches showed that miR‐31a‐5p inhibited osteogenic differentiation by negatively regulating SATB2 expression.…”
Section: Discussionmentioning
confidence: 99%
“…In vertebrate skeletogenesis, SATB2 has been implicated as a key component of a transcriptional network that regulates skeletal development and osteoblast differentiation (Dobreva et al, ; Zhao et al, ). Our previous results suggested that SATB2 plays a potential role in regulating the stemness, autophagy, and anti‐aging properties of craniofacial BMSCs (Dong et al, ; Zhou et al, ). Besides, estrogen has been reported that it inhibits senescence‐like phenotype in human mammary epithelial cells (Liu et al, ) and enhances osteogenesis in rat bone (Jagger, Chow, & Chambers, ).…”
Section: Introductionmentioning
confidence: 98%
“…These data strongly suggest that SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation [ 14 ]. Our previous studies have revealed that SATB2 is critically involved in site-specific characteristics, such as osteogenesis, stemness and senescence of BMSCs from rat jaws [ 15 ]. Importantly, the induced pluripotent stem cells with SATB2 overexpression significantly enhanced bone regeneration and repair both in vitro and in vivo, underscoring its therapeutic potential for craniofacial bone regeneration [ 16 ].…”
Section: Introductionmentioning
confidence: 99%