Roles of interferon induced protein with tetratricopeptide repeats (IFIT) family in autoimmune disease

The Role of Interferon-Induced Proteins with Tetratricopeptide Repeats 1 and 2 in Sepsis-Induced Acute Liver Injury

“…28,29 Notably, Chang et al 30 proposed that the enforced expression of IFIT1 conferred protection against the LPS-induced fatal hepatitis, thereby contributing to the mitigation of inflammatory liver diseases. Additionally, some studies have revealed that the 17 In alignment with previous research, our study sheds lights on the notable reduction in the expression of IFIT1 and IFIT2 in PBMCs derived from SALI patients. This underscores the potential of IFIT1 and IFIT2 as the high-sensitivity diagnostic biomarkers for SALI.…”

“…Additionally, some studies have revealed that the elevated levels of IFIT1 and IFIT2 enhance antiviral activity, thereby playing a role in both HCV infection and treatment. 17 …”

“…Furthermore, given their significant associations with a spectrum of autoimmune diseases, they are the potential therapeutic targets, offering a promising avenue for the future treatment interventions. 17 According to previous bioinformatics analysis, multiple proteins show significantly aberrant expression in SALI, including IFIT1 and IFIT2. 18 Therefore, the roles of IFIT1 and IFIT2 in the pathogenesis and development of SALI remains uncertain, emphasizing the need for further investigation.…”

Integrated analysis of single-cell RNA-seq and chipset data unravels PANoptosis-related genes in sepsis

“…The specific expression of IFI44 and IFIH1 in B cells with high PANscores underscores their pivotal role in modulating immune responses in sepsis. IFIT1 and IFIT2, although known for antiviral properties, were broadly expressed, suggesting their roles extend beyond viral defense to broader immune regulatory functions in sepsis ( 30 , 31 ). Similarly, RSAD2’s constrained expression pattern in certain immune cells points to its specific involvement in PANoptosis within the sepsis context.…”