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Cited by 4 publications
(4 citation statements)
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“…We further confirmed the result by PCR array analysis. The PCR array result showed, ectopic expression of TTPAL activated the expression of PI3K/AKT signaling-related genes while downregulated tumor suppressors, such as RBL2, PTEN, and CDKN1B (p27) [ 6 , 7 ] (Fig. 4B ).…”
Section: Resultsmentioning
confidence: 99%
“…We further confirmed the result by PCR array analysis. The PCR array result showed, ectopic expression of TTPAL activated the expression of PI3K/AKT signaling-related genes while downregulated tumor suppressors, such as RBL2, PTEN, and CDKN1B (p27) [ 6 , 7 ] (Fig. 4B ).…”
Section: Resultsmentioning
confidence: 99%
“…These genes may regulate tumor progression through different pathways. CDKN1B can shift from cyclin-dependent kinase inhibitor to oncogene by regulating the cell cycle in a cyclin-dependent kinase-dependent or -independent manner ( 36 , 50 ). SOX11, a transcription factor, mainly regulates progenitor and stem cell behavior during embryogenesis, and it also expressed in a wide variety of cancer types, such as neck cancer, malignant glioma, ovarian cancer and breast cancer ( 40 , 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…5D). To confirm whether the LINC01635 could regulate a series of tumor-related genes through miR-455-5p, several miR-455-5p-targeting genes (CPEB1, TMED2, HDAC4, STK24, CDKN1B, UBE2V1, USP3, RAB18 and SOX11) that are involved in multiple cancer types were examined (32)(33)(34)(35)(36)(37)(38)(39)(40). The majority of these genes were downregulated when knocking down LINC01635 in lung cancer cells, and similar regulation was also observed when overexpressing miR-455-5p (Fig.…”
Section: Linc01635 Can Bind With Mir-455-5p and Regulates The Express...mentioning
confidence: 99%
“…CDKN1B (cyclin‐dependent kinase inhibitor 1B), also known as p27 Kip1 , is an important cell cycle inhibitor protein that prevents or slows down cell division. Due to its function in cell cycle inhibition, its expression is often reduced in tumor cells . In a recent study, a 4‐bp deletion that modifies the regulatory uORF in the 5′ UTR of the CDKN1B mRNA was discovered in patients with tumors in the pituitary gland or pancreas.…”
Section: Translation Dysregulation In Cancermentioning
confidence: 99%