2007
DOI: 10.1016/j.freeradbiomed.2007.05.037
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Abstract: Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a few. Alzheimer disease (AD) is an age-related neurodegenerative disorder that is recognized as the most common form of dementia. AD is histopathologically characterized by the presence of extracellular amyloid plaques, intracellular neurofibrillary tangles, the presence of oligomers of amyloid beta-peptide (Abeta), and synapse loss.… Show more

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Cited by 480 publications
(425 citation statements)
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References 268 publications
(425 reference statements)
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“…At this time cells were treated with 10 M A␤ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Cells were harvested in 2% SDS buffer as described above at 4,8,12,16,24,36, and 48 h post-A␤ treatment. PDK1 and LDHA were visualized by Western blot analysis as described above, and protein quantification was performed using ImageJ software.…”
Section: Methodsmentioning
confidence: 99%
“…Overall, cellular ROS levels have been previously shown to increase when cells are treated with stressors such as A␤ (6,8). We therefore sought to examine if the cellular levels of ROS were altered in B12 cells overexpressing LDHA or PDK1.…”
Section: Overexpression Of Ldha or Pdk1 Decreases Oxygen Consumption mentioning
confidence: 99%
“…Their results have focused on about 15 proteins that have broad cellular functions and are distributed across several different organelles or cellular compartments. This work has been reviewed recently in this journal [92]. Notably, there is at least partial overlap in the oxidized proteins identified by this approach in tissue from patients with MCI or LOAD.…”
Section: Autopsymentioning
confidence: 98%
“…For example, although it is known that alterations in redox homeostasis contribute to the pathogenesis of disorders like Parkinson's disease, Alzheimer's disease and Huntington's disease, basic questions -such as whether the principal targets of oxidation are neurons or glial cells -remain unanswered [12,13]. Current spectrophotometric and proteomic techniques rely upon sub-cellular fractionation of total tissue homogenates.…”
mentioning
confidence: 99%
“…But, as shown in Figure 5b, DEM treatment did not decrease cell viability in this period. To address whether this increase of g-secretase activity was linked to the elevation of Ab secretion, we administered DEM to primary cortical cultures from Tg2576, human Swedish As it is well known that Ab also increases oxidative stress via several pathways, 22,23 we examined whether the oxidative stress generated by exogenous treatment with Ab increased g-secretase activity. CHO-C99 cells treated with synthetic Ab 42 peptide for 24 h indeed showed increased g-secretase activity in a dose-dependent manner (Figure 5f).…”
Section: Resultsmentioning
confidence: 99%