volume 31, issue 22, P6383-6391 2003
DOI: 10.1093/nar/gkg839
View full text
Has erratum
|
Sign up to set email alerts
|
Share

Abstract: Many tRNA molecules that recognize the purine-ending codons but not the pyrimidine-ending codons have a modified uridine at the wobble position, in which a methylene carbon is attached directly to position 5 of the uracil ring. Although several models have been proposed concerning the mechanism by which the 5-substituents regulate codon-reading properties of the tRNAs, none could explain recent results of the experiments utilizing well-characterized modification-deficient strains of Escherichia coli. Here, we …

Expand abstract
Editorial notices