Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

Maurya, Pramod Kumar; Mishra, Alok; Yadav, Birendra Singh; Singh, Vijay Pratap; Kumar, Prashant; Chaudhary, Amit; Srivastava, Shweta; Murugesan, Suriya Narayan; Mani, Ashutosh

doi:10.7150/jca.17689

Cited by 61 publications

(54 citation statements)

References 102 publications

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“…YBX1 in the nucleus plays a major role as a transcription factor for various drug resistance‐related genes, including ABCB1 , and in the repair of damaged DNA. However, in the cytoplasm, YBX1 is mainly involved in post‐transcriptional control of several mRNA splices, including epithelial‐to‐mesenchymal transition‐related genes . In the present review, we focus on the oncogenic role of YBX1, its localization in the nucleus, and its association with drug resistance.…”

Section: Y‐box Binding Protein‐1 Transcriptionally Activates Abc Tranmentioning

confidence: 99%

“…Similarly, carcinogenesis and further malignant progression of cancer are associated with the nine hallmarks of cancer, including cell proliferation, survival, immortalization, inflammation, invasion, metastasis, and others . In addition, most of the hallmarks are closely coupled with enhanced expression of YBX1 …”

Section: Enhanced Ybx1 Expression Predicts Poor Outcomes In Various Hmentioning

confidence: 99%

“…However, in the cytoplasm, YBX1 is mainly involved in post-transcriptional control of several mRNA splices, including epithelial-to-mesenchymal transition-related genes. 31,32 In the present review, we focus on the oncogenic role of YBX1, its localization in the nucleus, and its association with drug resistance.…”

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confidence: 99%

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Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer

Kuwano¹,

Shibata

Watari

et al. 2019

Cancer Science

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Y‐box binding protein‐1 ( YBX 1), a multifunctional oncoprotein containing an evolutionarily conserved cold shock domain, dysregulates a wide range of genes involved in cell proliferation and survival, drug resistance, and chromatin destabilization by cancer. Expression of a multidrug resistance‐associated ATP binding cassette transporter gene, ABCB 1 , as well as growth factor receptor genes, EGFR and HER 2/ErbB2 , was initially discovered to be transcriptionally activated by YBX 1 in cancer cells. Expression of other drug resistance‐related genes, MVP / LRP , TOP 2A , CD 44 , CD 49f , BCL 2 , MYC , and androgen receptor ( AR ), is also transcriptionally activated by YBX 1, consistently indicating that YBX 1 is involved in tumor drug resistance. Furthermore, there is strong evidence to support that nuclear localization and/or overexpression of YBX 1 can predict poor outcomes in patients with more than 20 different tumor types. YBX 1 is phosphorylated by kinases, including AKT , p70S6K, and p90 RSK , and translocated into the nucleus to promote the transcription of resistance‐ and malignancy‐related genes. Phosphorylated YBX 1, therefore, plays a crucial role as a potent transcription factor in cancer. Herein, a novel anticancer therapeutic strategy is presented by targeting activated YBX 1 to overcome drug resistance and malignant progression.

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Section: Y‐box Binding Protein‐1 Transcriptionally Activates Abc Tranmentioning

confidence: 99%

Section: Enhanced Ybx1 Expression Predicts Poor Outcomes In Various Hmentioning

confidence: 99%

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Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer

Kuwano¹,

Shibata

Watari

et al. 2019

Cancer Science

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“…YB1 promotes SG assembly by controlling translation of an essential SG protein, G3BP1 . In various tumor types including metastatic tumors, YB1 is frequently overexpressed, which correlates with drug resistance and poor prognosis . Blocking SG formation in a mouse tumor implantation model by knocking down YB1 or G3BP1 reduces invasive and metastatic tumors, suggesting that the presence of SGs promotes metastasis .…”

Section: Biomolecular Condensates In Cancermentioning

confidence: 99%

Biomolecular condensates in neurodegeneration and cancer

Spannl

Tereshchenko

Mastromarco

et al. 2019

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The intracellular environment is partitioned into functionally distinct compartments containing specific sets of molecules and reactions. Biomolecular condensates, also referred to as membrane‐less organelles, are diverse and abundant cellular compartments that lack membranous enclosures. Molecules assemble into condensates by phase separation; multivalent weak interactions drive molecules to separate from their surroundings and concentrate in discrete locations. Biomolecular condensates exist in all eukaryotes and in some prokaryotes, and participate in various essential house‐keeping, stress‐response and cell type‐specific processes. An increasing number of recent studies link abnormal condensate formation, composition and material properties to a number of disease states. In this review, we discuss current knowledge and models describing the regulation of condensates and how they become dysregulated in neurodegeneration and cancer. Further research on the regulation of biomolecular phase separation will help us to better understand their role in cell physiology and disease.

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“…[43], в котором обсуждаются возможности использования YB-1 в качестве биологического маркера и терапевти-ческой мишени при различных онкологических забо-леваниях. Однако, на наш взгляд, секретируемой фор-ме этого белка внимания уделено недостаточно.…”

Section: Yb-1 и секреторный фенотип клеточных популяцийunclassified

Secreted protein YB-1 and its prognostic significance

Stavrovskaya¹,

Моисеева²,

Генс³

et al. 2017

Usp. mol. onkol

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Введение Данный обзор посвящен секретируемому белку YB-1 (secreted Y box-binding protein 1, сYB-1). Однако основные сведения относительно участия этого белка в процессах канцерогенеза и опухолевой прогрессии получены при изучении внутриклеточного белка YB-1, поэтому сначала остановимся на его значении для жиз-недеятельности клетки, связанном с его цитоплазмен-ной и ядерной локализацией. YB-1 -многофункцио-нальный белок, принадлежащий к суперсемейству белков, обладающих эволюционно консервативным доменом холодового шока (CSD), взаимодействующих с ДНК и РНК клетки [1,2].Интерес к YB-1 и его внутриклеточной локализации начался с работы R. C. Bargou и соавт. в 1997 г., в кото-рой было показано, что YB-1 является транскрипци-онным фактором для гена MDR1, кодирующего белок Р-гликопротеин, основного АВС-транспортера, ответ-ственного за множественную лекарственную устойчи-вость [3]. С этого момента количество работ, посвящен-ных YB-1 как в связи с множественной лекарственной устойчивостью [4,5], так и с другими аспектами опу-холевой прогрессии постоянно возрастало. Показано, что YB-1 участвует в регуляции многих клеточных про-цессов, включая пролиферацию, дифференцировку и ответ на стрессовые воздействия [6,7].

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Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

Cited by 61 publications

References 102 publications

Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer

Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer

Biomolecular condensates in neurodegeneration and cancer

Secreted protein YB-1 and its prognostic significance

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