Role of “Western Diet” in Inflammatory Autoimmune Diseases

Abstract

Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the “Western diet”, including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and ‘fast foods’, promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of “Western diet” with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.

Chiropractic Management of a Patient With Chronic Fatigue: A Case Report

“…34,35 In addition to the normalization of HPA measures, recommending an anti-inflammatory ancestral diet 36,37 likely assisted in decreasing thyroid autoimmunity. 38 Normalization of HPA axis function was also assisted by specific targeted supplementation based on adrenal function panel results, each with its own mechanism. Licorice root was used to increase the cortisol level by increasing the half-life of the hormone.…”

GUT-the Trojan Horse in Remote Organs’ Autoimmunity

“…However, when this equilibrium is breached, tolerance is affected, paving the way for immune dysregulations resulting in autoimmunity. The association between diet and the risk of developing ADs was proposed half a century ago and was reviewed lately [8,9]. Despite our increasing knowledge, little is known about the interplay of diet and gut microbiota in human immune-mediated diseases.…”

“…Like mentioned above, the exact role of diet as a risk factor in these conditions is less clear-cut. Even the more beneficial nutrients like polyunsaturated fatty acids, plant fiber, fish oils or the intake of vegetables and fresh fruits are far from establishing causality in ADs' prevention or therapy [8,9]. It seems that the nutritional exposome is far from explaining human reactome.…”

Efeito dos compostos fenólicos do camu-camu e do cupuaçu no desenvolvimento da obesidade e diabetes mellitus tipo 2

“…Atualmente, sabe-se que a microbiota intestinal influencia diversos processos imunitários e metabólicos, e mudanças em seu ecossistema podem contribuir para o desenvolvimento de obesidade e resistência à insulina (FALLUCA et al, 2014;MANZEL et al, 2014). Estudos tem demonstrado que dietas ricas em gorduras e açúcares são capazes de modular a microbiota, aumentando a quantidade de microorganismos patogênicos, alteração conhecida como disbiose (MYLES, 2014;TREMAROLI;BACKHED, 2012).…”

“…O índice de massa corporal (IMC) é utilizado para avaliar esse excesso de gordura corporal, sendo indivíduos com IMC entre 25 e 30 considerados com sobrepeso e IMC maior que 30 como obesos (OMS, 2015b). Acredita-se que o desequilíbrio no balanço energético, resultante de fatores ambientais, comportamentais como também de fatores genéticos, é um fator determinante no aumento da incidência da obesidade a qual tomou proporções epidêmicas nos últimos anos atingindo bilhões de indivíduos mundialmente (MANZEL et al, 2014;.…”