Role of voltage-gated L-type Ca2+ channel isoforms for brain function

Striessnig, Jörg; Koschak, Alexandra; Sinnegger-Brauns, Martina J.; Hetzenauer, Alfred; Nguyen, Ngoc Khoi; Busquet, Perrine; Pelster, Gilda; Singewald, Nicolas

doi:10.1042/bst0340903

Cited by 165 publications

(148 citation statements)

References 53 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…In particular, activation of CREB has served as the quintessential model for this process (Deisseroth et al, 1996(Deisseroth et al, , 1998(Deisseroth et al, , 2003West et al, 2002). Extensive investigation of the pathways leading to CREB activation in hippocampal neurons has revealed a privileged role for Ca 2ϩ influx through Ca V 1.2 channels and the related Ca V 1.3 channels compared with other high voltage-activated (HVA) Ca 2ϩ channels (e.g., Ca V 2.1 or Ca V 2.2) (Striessnig et al, 2006). Because the distinguishing feature among different HVA Ca 2ϩ channels is the identity of the pore-forming ␣ 1 subunit, the advantage of Ca V 1.2 and Ca V 1.3 channels must be attributable to specific determinants within the ␣ 1 subunit rather than in the accessory ␤ or ␣ 2 ␦ subunits, which are common to all HVA channels (Ertel et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons

Wang¹,

George²,

Kim³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons

Wang¹,

George²,

Kim³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

“…Different channel compositions give rise to different gating properties of the LTCC and may influence the different rates of deactivation tail current (67)(68)(69)(70)(71). The class Ca v 1.2 ␣ 1 subunit has been shown to contribute to forming an LTCC with anomalous gating properties characterized by rare and short openings with very low open probability during depolarization but long openings with high open probability after repolarization (70,72). Isoforms of ␤ subunits suppress the prolonged tail current, probably by facilitated inactivation of the channel (73,74).…”

Section: Discussionmentioning

confidence: 99%

Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons

et al. 2006

View full text Add to dashboard Cite

It has been shown that presenilin is involved in maintaining Ca 2؉ homeostasis in neurons, including regulating endoplasmic reticulum (ER) Ca 2؉ storage. From studies of primary cultures and cell lines, however, its role in stress-induced responses is still controversial. In the present study we analyzed the effects of presenilin mutations on membrane currents and synaptic functions in response to stress using an in vivo preparation. We examined voltage-gated K ؉ and Ca 2؉ currents at the Drosophila larval neuromuscular junction (NMJ) with voltage-clamp recordings. Our data showed that both currents were generally unaffected by loss-of-function or Alzheimer's disease (AD) -associated presenilin mutations under normal or stress conditions induced by heat shock (HS) or ER stress. In larvae expressing the mutant presenilins, prolonged Ca 2؉ tail current, reflecting slower deactivation kinetics of Ca 2؉ channels, was observed 1 day after stress treatments were terminated. It was further demonstrated that the L-type Ca 2؉ channel was specifically affected under these conditions. Moreover, synaptic plasticity at the NMJ was reduced in larvae expressing the mutant presenilins. At the behavioral level, memory in adult flies was impaired in the presenilin mutants 1 day after HS. The results show that presenilin function is important during the poststress period and its impairment contributes to memory dysfunction observed during adaptation to normal conditions after stress. Our findings suggest a new stress-related mechanism by which presenilin may be implicated in the neuropathology of

show abstract

“…1D) is an interesting possibility that needs to be verified. Indeed, the co-existence of two L-type channel isoforms in chromaffin cells, as shown in cardiac tissues, smooth muscles, ␤-pancreatic cells and sensory neurons (see [51]), raises three interesting questions concerning the role that the two channel isoforms play in the control of Ca 2+ -dependent processes in neuroendocrine cells. Do Cav1.2 and Cav1.3 control different cell functions?…”

Section: Two Functionally Active L-type Channels In Chromaffin Cells?mentioning

confidence: 99%

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

et al. 2007

View full text Add to dashboard Cite

Voltage-gated L-type (Cav1.2 and Cav1.3) channels are widely expressed in cardiovascular tissues and represent the critical drug-target for the treatment of several cardiovascular diseases. The two isoforms are also abundantly expressed in neuronal and neuroendocrine tissues. In the brain, Cav1.2 and Cav1.3 channels control synaptic plasticity, somatic activity, neuronal differentiation and brain aging. In neuroendocrine cells, they are involved in the genesis of action potential generation, bursting activity and hormone secretion.Recent studies have shown that Cav1.2 and Cav1.3 are also expressed in chromaffin cells but their functional role has not yet been identified despite that L-type channels possess interesting characteristics, which confer them an important role in the control of catecholamine secretion during action potentials stimulation. In intact rat adrenal glands L-type channels are responsible for adrenaline and noradrenaline release following splanchnic nerve stimulation or nicotinic receptor activation. L-type channels can be either up-or down-modulated by membrane autoreceptors following distinct second messenger pathways. L-type channels are tightly coupled to BK channels and activate at relatively low-voltages. In this way they contribute to the action potential hyperpolarization and to the pace-maker current controlling action potential firings. L-type channels are shown also to regulate the fast secretion of the immediate readily releasable pool of vesicles with the same Ca 2+ -efficiency of other voltage-gated Ca 2+ channels. In mouse adrenal slices, repeated action potential-like stimulations drive L-type channels to a state of enhanced stimulus-secretion efficiency regulated by ␤-adrenergic receptors.Here we will review all these novel findings and discuss the possible implication for a specific role of L-type channels in the control of chromaffin cells activity.

show abstract

Role of voltage-gated L-type Ca2+ channel isoforms for brain function

Cited by 165 publications

References 53 publications

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons

Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

Contact Info

Product

Resources

About

Role of voltage-gated L-type Ca2+ channel isoforms for brain function

Cited by 165 publications

References 53 publications

Ca2+/Calmodulin Regulates Trafficking of CaV1.2 Ca2+Channels in Cultured Hippocampal Neurons

Ca2+/Calmodulin Regulates Trafficking of CaV1.2 Ca2+Channels in Cultured Hippocampal Neurons

Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

Contact Info

Product

Resources

About

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons

Ca²⁺/Calmodulin Regulates Trafficking of Ca_V1.2 Ca²⁺Channels in Cultured Hippocampal Neurons