Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction

Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease

“…An association between vitamin B 12 deficiency and increased Hcy was observed in this study; however, the Hcy levels were not affected by folate concentrations. In the study of Iqbal et al [46] in individuals with folate and vitamin B 12 deficiencies the mean Hcy level was significantly increased compared to individuals with normal vitamin status.…”

Serial changes in plasma homocysteine in acute clinical stroke

“…Hyperhomocysteinemia has been found to be common in normal populations of South Asia including Pakistan (Southern parts mostly) [19][20][21]. In addition to stroke participants, our healthy control participants also showed moderate hyperhomocysteinemia.…”

The Levels of Serum B12, Folic Acid and Homocysteine in the Thromboembolic Diseases

“…On the other hand, plasma hcy levels were higher. This study suggested vitamin B12, B6, and folic acid replacement be considered in populations at risk to prevent the development of CAD [20]. Guo at al., in their study of unstable angina pectoris (UAP) patients, identified 22 cases with hyperhomocysteinemia (hhcy) and treated them with 5mg/day folic acid for 8 weeks.…”