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Cited by 51 publications
(15 citation statements)
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References 19 publications
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“…Recently, vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), both gastrointestinal hormones, have been reported to drive GH secretions in acromegalics in vitro [18][19][20] and in vivo [18,21] but not in normal subjects [18][19][20][21]. GIP as well as PHM is a member of the VIP Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), both gastrointestinal hormones, have been reported to drive GH secretions in acromegalics in vitro [18][19][20] and in vivo [18,21] but not in normal subjects [18][19][20][21]. GIP as well as PHM is a member of the VIP Fig.…”
Section: Discussionmentioning
confidence: 99%
“…56 for review). Similarly, VIP does not stimulate GH release in normal humans (10,38). Galanin affects GH secretion primarily at the hypothalamic level by acting on neurons to release GHRH (47); direct pituitary effects are modest and seen only at pharmacological levels (42,43).…”
Section: Discussionmentioning
confidence: 99%
“…PHIlike immunoreactivity is also present in the hypophysial portal plasma in rats [5]. It has been reported that VIP stimulates GH release, both in vivo and in vitro, in rats [6], acromegalic patients [7,8] and in vitro in the goat [9]. VIP was reported to stimulate GH release in ovariectomized rats but the effect only occurred when VIP was injected into the third ventricle, suggesting a hypothalamic site of action [10].…”
mentioning
confidence: 98%