Role of Uric Acid Albumin Ratio in Predicting Development of Acute Kidney Injury and Mortality in Intensive Care Unit Patients

Yeter, Hasan; Eyupoglu, Damla; Pasayev, Tural; Çetik, Sıla; Akcay, Omer Faruk; Yıldırım, Tolga

doi:10.5152/turkjnephrol.2019.3416

Cited by 7 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 16 , 30 , 31 Yeter et al found that a sUAR > 1.7 was significantly associated with AKI in critically ill patients. 15 Recently, Faysal et al also demonstrated that sUAR (>1.62) had a greater predictive value for contrast-induced nephropathy, and was superior to serum uric acid and albumin. 17 In our study, we found that sUAR had a moderate predictive value for PC-AKI after PCI in patients with STEMI, and it was also superior to serum uric acid and albumin.…”

Section: Discussionmentioning

confidence: 97%

“… 14 The serum uric acid/albumin ratio (sUAR), which is derived from serum uric acid and serum albumin, has been reported as a novel inflammatory marker in predicting AKI, and is associated with mortality in patients with AKI. 15 , 16 Recently, Faysal et al conducted a retrospective study and found that sUAR was an independent predictor of contrast-induced nephropathy. 17 However, the sample size was relatively small and the definition of contrast-induced nephropathy was proved to be not often use in patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Zhang¹,

Xu²,

He³

et al. 2022

JIR

View full text Add to dashboard Cite

Background The serum uric acid/albumin ratio (sUAR), a novel inflammatory marker, effectively predicts acute kidney injury (AKI) and cardiovascular outcomes. However, whether the sUAR predicts post-contrast acute kidney injury (PC-AKI) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) remains uncertain. In this study, we evaluated the association between the sUAR and PC-AKI in patients with STEMI undergoing PCI. Methods We consecutively recruited patients with STEMI who underwent PCI and stratified them into three groups according to the terciles of the sUAR. The primary outcome was the incidence of PC-AKI. The association between the sUAR and PC-AKI was assessed by multivariate logistic regression analysis. Results A total of 2861 patients with STEMI were included in this study. The incidence of PC-AKI increased stepwise with increasing sUAR tercile (2.6% vs 4.0% vs 11.6%, p < 0.001), and the incidence of in-hospital major adverse clinical events (MACEs) was highest among patients in the Q3 group. Multivariate logistic regression analysis revealed that the sUAR was also an independent predictor of PC-AKI (continuous sUAR, per 1-unit increase, odds ratio [OR] [95% confidence interval (CI)]: 1.06 [1.02–1.10], p = 0.005; tercile of sUAR, OR [95% CI] for Q2 and Q3: 1.18 [0.69–2.01] and 1.85 [1.12–3.06], respectively, with Q1 as a reference) but not in-hospital MACEs. In the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) of the sUAR for predicting PC-AKI was 0.708 (95% CI: 0.666–0.751), and ROC analysis also showed that the sUAR was superior to uric acid and albumin alone in predicting PC-AKI. Conclusion Increasing sUAR was significantly associated with a higher risk of PC-AKI but not in-hospital MACEs in patients with STEMI who underwent PCI, suggesting that sUAR had a predictive value for PC-AKI after PCI in patients with STEMI. Further studies are required to confirm this finding.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Zhang¹,

Xu²,

He³

et al. 2022

JIR

View full text Add to dashboard Cite

show abstract

“…Factors that decrease synthesis include a high colloid osmotic pressure, inflammation, malnutrition, diabetes, liver disease, and infections, and the mechanisms of its degradation are poorly understood [14]. Common conditions in ill patients, such as malnutrition, infections, inflammation, congestive heart failure, and renal diseases, can affect the levels of UA and SA [31]; they might be involved in different phases of vascular damage [12]. As a result of this knowledge, we decided to assay UAR to increase each variable's separate predictive value and compare them to other previously proven inflammatory markers of CAD, CAR, and NLR.…”

Section: Discussionmentioning

confidence: 99%

Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction

Çakmak

Bayam

Çelık

et al. 2020

Pulse

View full text Add to dashboard Cite

Objective: This research aimed to investigate the predictive value of the uric acid-to-serum albumin ratio (UAR) in establishing the severity and extent of coronary artery disease (CAD) with non-ST segment elevation myocardial infarction (NSTEMI) patients. Methods: A total of 402 patients (mean age 63.5 ± 11.6 years) were included in this retrospectively designed study. We compared Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Scores (SS) between low (≤22) and intermediate-high (>22) groups. The UAR, the neutrophil-to-lymphocyte ratio (NLR), and the C-reactive protein-to-albumin ratio (CAR) were evaluated and compared. Results: SS >22 were observed in 30.8% (n = 124) of the patients, and their UAR, NLR, and CAR were significantly higher. Three separate multivariate analysis models performed as the outcome of a reliable correlation between UAR, NLR, CAR, and consequently UAR (OR = 2.08; 95% CI 1.21–3.58; p = 0.008) and CAR (OR = 3.33; 95% CI 1.85–5.9; p < 0.001) reached significance but NLR (OR = 1.26; 95% CI 0.86–1.84; p = 0.20) clinically trended significance (not statistically). Model performance comparisons demonstrated that UAR is a better predictor regarding likelihood ratios (UAR, 60.95; NLR, 57.8; and CAR, 59.0). Conclusion: As a novel inflammatory marker, UAR independently predicted better outcomes than CAR and might be used reliably in prediction of the extent of CAD in NSTEMI patients.

show abstract

“…In a study conducted by Yeter et al [ 12 ], UA/A ratio was found to be associated only with the development of AKI, and its relation with mortality could not be determined. We determined that the UA/A ratio is associated with an increased 30-day mortality risk in patients who develop AKI in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Hypoalbuminemia and hyperuricemia have been associated with AKI and result in increased mortality [ 10 , 11 ]. According to Yeter et al [ 12 ], Uric acid albumin ratio (UA/A) higher than 1.7 was significantly associated with AKI and 28-day mortality. In this study, we investigate the relationship between UA/A ratio and short-term mortality in patients who have AKI.…”

Section: Introductionmentioning

confidence: 99%

Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury

et al. 2021

View full text Add to dashboard Cite

Objective We aimed to investigate uric acid and albumin ratio (UA/A) as a marker of short-term mortality in acute kidney injury (AKI). Both uric acid and albumin are strongly correlated with the development and mortality of AKI. MethodsThe patients hospitalized from May 2019 to September 2019 for AKI were included in this study. The diagnostic odds ratio (DOR), Youden index (J), and the area under a receiver operating characteristic curve (AUROC) determined a cut-off UA/A ratio for mortality. Cox-regression analysis was performed to identify UA/A as a prognostic marker of the 30-day mortality rate.Results A total of 171 patients with an average age of 69.20 ± 13.0 (45.6% women) were included in the study. The average UA/A ratio was 3.3 ± 1.5 mg/g and 2.5 ± 1.0 mg/g in the nonsurvivor and survivor groups, respectively (P = 0.001). The best cut-off UA/A ratio associated with mortality was determined as 2.4 mg/g with a specificity of 52% and a sensitivity of 77% (DOR, 3.6; J, 28.8; AUROC, 0.644). Thirty-day cumulative survival rates of the low and high UA/A ratio groups were 85.9 ± 4.0% and 63.7 ± 5.0%, respectively. The estimated survival times of the low and high UA/A ratio groups were 27.7 days (95% confidence interval [CI], 26.2-29.3) and 23.9 days (95% Cl, 22.0-25.9), respectively. ConclusionWe found a direct correlation between 30-day mortality and UA/A ratio at initial presentation in AKI patients regardless of age, comorbidities, and clinical and laboratory findings, including albuminuria.

show abstract

Role of Uric Acid Albumin Ratio in Predicting Development of Acute Kidney Injury and Mortality in Intensive Care Unit Patients

Cited by 7 publications

References 0 publications

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction

Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury

Contact Info

Product

Resources

About