1974
DOI: 10.1038/icb.1974.10
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Abstract: Summary The contributions of different afferent pathways to the reflex apnoea in expiration, mild hypertension and marked bradycardia evoked in unanaesthetized rabbits by nasal inhalation of cigarette smoke, formaldehyde, ammonia and benzene vapour were defined according to a factorial experimental design. Animals were used with (1) trigeminal nerve ablation, (2) olfactory bulb ablation, (3) total and selective section of the carotid sinus and aortic nerves, and (4) combinations of the above lesions. Trigemina… Show more

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Cited by 44 publications
(11 citation statements)
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“…Similar cardiorespiratory responses, including an abrupt and dramatic bradycardia, also is induced in rats to nasal stimulation with irritant vapors (McRitchie and White, 1974; White et al, 1974, 1975; Panneton, 1991b; Gieroba et al, 1994; Panneton and Yavari, 1995; Yavari et al, 1996; McCulloch and Panneton, 1997; McCulloch et al, 1999a,b; Panneton et al, 2010b). We recently reported on neurons activated during underwater submersion in voluntarily diving rats with the aid of the cFos technique (Panneton et al, 2012), but such studies allow no distinction as to the function of these activated neurons.…”
Section: Introductionmentioning
confidence: 83%
“…Similar cardiorespiratory responses, including an abrupt and dramatic bradycardia, also is induced in rats to nasal stimulation with irritant vapors (McRitchie and White, 1974; White et al, 1974, 1975; Panneton, 1991b; Gieroba et al, 1994; Panneton and Yavari, 1995; Yavari et al, 1996; McCulloch and Panneton, 1997; McCulloch et al, 1999a,b; Panneton et al, 2010b). We recently reported on neurons activated during underwater submersion in voluntarily diving rats with the aid of the cFos technique (Panneton et al, 2012), but such studies allow no distinction as to the function of these activated neurons.…”
Section: Introductionmentioning
confidence: 83%
“…However, responses similar to those seen during underwater submersion of marine mammals can be elicited in smaller laboratory mammals. For example, stimulation of the nasal mucosa of laboratory mammals with irritant vapors (15,26,32,57,60,71,73,74,76,79,81,99,100,103) also elicits dramatic changes in cardiorespiratory function similar to those seen in aquatic mammals with submersion. This feature is advantageous since various pharmacological and physiological tests can be done on table preparations in a more controlled laboratory setting.…”
mentioning
confidence: 91%
“…Moreover, such sensations, including pain, can be elicited from stimulating the human nasal mucosa (Handwerker and Kobal, 1993; Thürauf et al, Cometto-Muñiz and Cain, 1997; 1993; Cometto-Muniz et al, 1998, 2001; Hummel et al, 2003). In addition, it long has been demonstrated that stimulating paranasal areas induces autonomic adjustments (Angell James and de Burgh Daly, 1972; McRitchie and White, 1974; Drummond and Jones, 1979; Panneton, 1990; Gieroba et al, 1994; Kratschmer, 2001) similar to those of the mammalian diving response.…”
Section: Introductionmentioning
confidence: 99%