Abstract:Background: Rheumatoid arthritis (RA) is a systemic disease that causes progressive joint damage and disability.Inflammatory cytokines, including tumor necrosis factor (TNF), and IL-6, which are mainly produced bymacrophages, play a central role in the development of synovitis. For example, TNF play major role in theexpression of adhesion molecules and inflammatory chemokines which, in combination, facilitate increaseinflammatory leukocytes and severe inflammatory responses.In addition to environmental factors… Show more
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