Role of therapeutic fasting in women's health: An overview

Nair, Pradeep M.K.; Khawale, Pranav G

doi:10.4103/0976-7800.185325

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…The first is that even though fasting has been utilized by humans for millennia and the medical community for at least a century it was not until 2013 that peer-reviewed fasting guidelines were published in the English language. These guidelines as well as an increase in scientific literature on the benefits of various types of fasting support the credibility and emerging acceptance of this intervention [ 4 , 53 – 55 ]. The second point is that within the fasting community – not to mention the greater medical community – there are claims, unsubstantiated by research, about the utilization and safety of water-only fasting (i.e., that it is not utilized and unsafe).…”

Section: Discussionmentioning

confidence: 99%

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting

Finnell

Saul²,

Goldhamer³

et al. 2018

BMC Complement Altern Med

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BackgroundEvidence suggests that fasting, during which only water is consumed, results in potentially health promoting physiological effects. However, peer-reviewed research assessing the safety of water-only fasting is lacking. To address this, we conducted a chart review to describe adverse events (AEs) that occurred during medically supervised, water-only fasting.MethodsElectronic charts from patient visits to a residential medical facility from 2006 to 2011 were reviewed. Patients who were at least 21 years of age and water-only fasted for ≥2 consecutive days with a refeeding period equal to half of the fast length were included. Out of 2539 charts, 768 visits met our inclusion and exclusion criteria. AEs were abstracted from chart notes and classified according to CTCAE (v4.03) and MedDRA (v12.1) terminology. Descriptive analysis of AEs is reported.ResultsDuring the protocol period, the highest grade AE (HGAE) in 555 visits was a grade 2 event or lower, in 212 visits it was a grade 3 event, in 1 visit it was a grade 4 event, and there were no grade 5 events. There were 2 (0.002%) visits with a serious adverse event (SAE). The majority of AEs identified were mild (n = 4490, 75%) in nature and known reactions to fasting.ConclusionsTo our knowledge, this is the most comprehensive analysis of AEs experienced during medically supervised, water-only fasting conducted to date. Overall, our data indicate that the majority of AEs experienced were mild to moderate and known reactions to fasting. This suggests that the protocol used in this study can be safely implemented in a medical setting with minimal risk of a SAE.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2136-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting

Finnell

Saul²,

Goldhamer³

et al. 2018

BMC Complement Altern Med

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“…During the last decade the health‐promoting and life‐extending effects of a wide variety of variants of a standard CR diet have been examined in both humans and models species 29, 57, 58, 59, 60, 61, 62. The major differences between the dietary variants of intermittent calorie restriction are (1) the extent of calorie reduction varying from complete fasting to a mild decrease in calorie intake and (2) the time window when the fasting/CR is applied in combination with the period in between the fasting/CR cycles.…”

Section: Discussionmentioning

confidence: 99%

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Lute

Boekschoten

Dijk

et al. 2017

Molecular Nutrition Food Res

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ScopeCalorie restriction (CR) has been shown to extend life‐ and health‐span in model species. For most humans, a life‐long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can (1) provide long‐term beneficial effects and (2) counteract diet‐induced obesity in male aging mice.Methods and resultsIn this study, we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate‐fat (MF) feeding. This weekly intermittent CR significantly counteracted the adverse effects of the MF diet on mortality, body weight, and liver health markers in 24‐month‐old male mice. Hepatic gene expression profiles of INT‐exposed animals appeared much more comparable to CR‐ than to MF‐exposed mice. At 12 months of age, a subgroup of MF‐exposed mice was transferred to the INT diet. Gene expression profiles in the liver of the 24‐month‐old diet switch mice were highly similar to the INT‐exposed mice. However, a small subset of genes was consistently changed by the MF diet during the first phase of life.ConclusionWeekly intermittent CR largely, but not completely, reversed adverse effects caused by a MF diet.

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“…As a "green and natural" therapy, CR has a significant effect on weight loss, which can alleviate a variety of diseases related to metabolic problems such as obesity, type 2 diabetes, cardiovascular disease, and cancer (13). It has been known that fasting can improve the reproductive and mental health in women (14). In terms of male fertility, weight-loss interventions result in an improvement of semen quality in obese men (15,16).…”

Section: Introductionmentioning

confidence: 99%

Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice

Zhang¹,

Zhang²,

Sun³

et al. 2021

Ann Transl Med

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Background: Obesity is a growing global public health problem. It has been associated with diabetes, cardiovascular disease, cancer, and an increased risk of all-cause mortality, as well as infertility. Calorie restriction (CR) is an effective life intervention to defend against obesity. This study aimed to investigate the effects of long-term moderate CR on the reproductive function and underlying mechanisms in a mouse model of obesity.Methods: Male C57BL/6 mice were randomized to two groups receiving either a standard diet (STD) or a high-fat diet (HFD) for 8 weeks to induce obesity. The HFD-induced obesity mice were further randomized into two groups: HFD group and CR group (reduced the mean amount of HFD by 25%). After 12 weeks, the body weight, testicular coefficients, fasting blood glucose (FBG), serum triglyceride (TG), and total cholesterol (TC) were detected and measured. The sperm quality was detected by an automatic sperm quality analyzer (SQA-V). The structure of testicular tissues was examined by hematoxylin and eosin (HE) staining. Testicular cell apoptosis was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. The levels of NAD-dependent deacetylase sirtuin-1 (SIRT1) and antioxidative enzymes were detected in the testes.Results: CR treatment reduced weight gain and increased testicle coefficients in HFD-induced obese mice.CR reduced the serum level of FBG, TG, and TC, and increased the serum levels of testosterone. Moreover, CR increased sperm count and motility, and sperm normality in obese mice. Furthermore, CR ameliorated the testicular morphological damage and cell apoptosis in obese mice. CR also attenuated the oxidative stress level and increased the protein expressions of SIRT1 in testicular tissues of obese mice.Conclusions: Long-term moderate CR improves obese male fertility, probably by alleviating oxidative stress via activation of SIRT1 signaling.

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Role of therapeutic fasting in women's health: An overview

Cited by 14 publications

References 34 publications

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice

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