volume 31, issue 8, P2408-2415 1992
DOI: 10.1021/bi00123a028
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Philippe Frachet, Alain Duperray, Elisabeth Delachanal, Gerard Marguerie

Abstract: Integrins are alpha beta heterodimers that play a major role in cell-cell contacts and in interactions between cells and extracellular matrices. Identification of structural domains that are critical for the expression of such receptors at the cell surface in a functional conformation is one of the major issues that has not yet been resolved. In the present study, the role of the cytoplasmic and transmembrane domains of each of the subunits has been examined using platelet GPIIb/IIIa as a prototypic integrin. …

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