volume 32, issue 9, P712-725 2017
DOI: 10.1590/s0102-865020170090000004
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Abstract: Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil 1 AbstractPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/ kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.…

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