Role of the lung microbiome in HIV pathogenesis

Shenoy, Meera K.; Lynch, Susan V.

doi:10.1097/coh.0000000000000427

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Microbiota dominated by Neisseria, Moraxella, or Haemophilus are associated with chronic respiratory diseases including asthma, COPD, and chronic rhinosinusitis among HIV-uninfected adult and pediatric populations 6 , 11 – 15 . In contrast, these findings have not consistently been supported in HIV-positive populations, where Streptococcus and Prevotella dominance has been associated with pulmonary inflammation, COPD, and short- and intermediate-term mortality among HIV-positive Ugandan adults hospitalized with acute pneumonia 9 , 16 , 17 . The association of Streptococcus and Prevotella microbiota with a lower relative risk of pediatric HIV-CLD in our study could be explained by three factors.…”

Section: Discussionmentioning

confidence: 83%

“…where Streptococcus and Prevotella dominance has been associated with pulmonary inflammation, COPD, and short-and intermediate-term mortality among HIV-positive Ugandan adults hospitalized with acute pneumonia 9,16,17 . The association of Streptococcus and Prevotella microbiota with a lower relative risk of pediatric HIV-CLD in our study could be explained by three factors.…”

Section: Discussionmentioning

confidence: 99%

“…Sequence data was converted to fastq format using bcl2fastq v2. 16.0.10 and paired sequencing reads with a 25 bp minimum overlap were merged using FLASH v1.2.11. Merged reads were demultiplexed in the absence of quality filtering using QIIME (Quantitative Insights into Microbial Ecology, v1.9.1) followed by quality filtering using the USEARCH fastq filter (v7.0.1001) to remove reads having > 2 expected errors.…”

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confidence: 99%

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Distinct lung microbiota associate with HIV-associated chronic lung disease in children

Bhadriraju

Fadrosh

Shenoy

et al. 2020

Sci Rep

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Chronic lung disease (CLD) is a common co-morbidity for HIV-positive children and adolescents on antiretroviral therapy (ART) in sub-Saharan Africa. In this population, distinct airway microbiota may differentially confer risk of CLD. In a cross-sectional study of 202 HIV-infected children aged 6–16 years in Harare, Zimbabwe, we determined the association of sputum microbiota composition (using 16S ribosomal RNA V4 gene region sequencing) with CLD defined using clinical, spirometric, or radiographic criteria. Forty-two percent of children were determined to have CLD according to our definition. Dirichlet multinomial mixtures identified four compositionally distinct sputum microbiota structures. Patients whose sputum microbiota was dominated by Haemophilus, Moraxella or Neisseria (HMN) were at 1.5 times higher risk of CLD than those with Streptococcus or Prevotella (SP)-dominated microbiota (RR = 1.48, p = 0.035). Cell-free products of HMN sputum microbiota induced features of epithelial disruption and inflammatory gene expression in vitro, indicating enhanced pathogenic potential of these CLD-associated microbiota. Thus, HIV-positive children harbor distinct sputum microbiota, with those dominated by Haemophilus, Moraxella or Neisseria associated with enhanced pathogenesis in vitro and clinical CLD.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Distinct lung microbiota associate with HIV-associated chronic lung disease in children

Bhadriraju

Fadrosh

Shenoy

et al. 2020

Sci Rep

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“…Parvimonas and Peptostreptococcus are oral pathogens that have been implicated in periodontal infections among HIV+ individuals 68,69 , and their damaging effects may be heightened in MA users due to MA’s proclivity to reduce saliva production. Finally, increased abundance of Veillonella has been linked with HIV-associated pulmonary diseases 70 . Our study, showing that MA impacted the relative abundance of each of these genera, may highlight mechanisms underlying the relationship between MA use, HIV acquisition and transmission risk, and HIV disease progression which warrant further investigation.…”

Section: Discussionmentioning

confidence: 99%

Alterations to the Gastrointestinal Microbiome Associated with Methamphetamine Use among Young Men who have Sex with Men

Cook

Fulcher

Tobin

et al. 2019

Sci Rep

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Methamphetamine (MA) use is a major public health problem in the United States, especially among people living with HIV (PLWH). Many MA-induced neurotoxic effects are mediated by inflammation and gut microbiota may play a role in this process, yet the effects of MA on the microbiome have not been adequately explored. Therefore, we performed 16S rRNA gene sequencing on rectal swab samples from 381 men who have sex with men, 48% of whom were PLWH and 41% of whom used MA. We compared microbiome composition between MA users and non-users while testing for potential interactions with HIV and controlling for numerous confounders using inverse probability of treatment weighting. We found that MA use explained significant variation in overall composition (R2 = 0.005, p = 0.008) and was associated with elevated Finegoldia, Parvimonas, Peptoniphilus, and Porphyromonas and reduced Butyricicoccus and Faecalibacterium, among others. Genera including Actinomyces and Streptobacillus interacted with HIV status, such that they were increased in HIV+ MA users. Finegoldia and Peptoniphilus increased with increasing frequency of MA use, among others. In summary, MA use was associated with a microbial imbalance favoring pro-inflammatory bacteria, including some with neuroactive potential and others that have previously been associated with poor HIV outcomes.

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“…P. copri increases the mucus layer permeability and increases propionate concentration and levels of fecal LCN-2, in agreement with previous studies reporting that P. copri exacerbates inflammation ( 6, 45 ). In addition, Prevotella enrichment within the lung microbiome of HIV-infected patients has been observed and is associated with Th17 inflammation ( 54 ). Prevotella sp.…”

Section: Discussionmentioning

confidence: 99%

Specific targeting of intestinalPrevotella copriby aListeria monocytogenesbacteriocin

Rolhion

Chassaing

Nahori

et al. 2019

Preprint

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Deciphering the specific function of every microorganism in microbial gut communities is a key issue to interrogate their role during infection. Here, we report the discovery of a Listeria bacteriocin, Lmo2776, that specifically targets the abundant gut commensal Prevotella copri and affects Listeria infection. Oral infection of conventional mice with a Δlmo2776 mutant leads to a thinner intestinal mucus layer and higher Listeria loads both in the intestinal content and deeper tissues compared to WT Listeria, while no difference is observed in germ-free mice. This microbiota-dependent effect is phenocopied by precolonization of germ-free mice before Listeria infection, with P. copri, but not with other commensals,. Together, these data unveil a role for Prevotella in controlling intestinal infection, highlighting that pathogens may selectively deplete microbiota to avoid excessive inflammation.

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Role of the lung microbiome in HIV pathogenesis

Cited by 10 publications

References 41 publications

Distinct lung microbiota associate with HIV-associated chronic lung disease in children

Distinct lung microbiota associate with HIV-associated chronic lung disease in children

Alterations to the Gastrointestinal Microbiome Associated with Methamphetamine Use among Young Men who have Sex with Men

Specific targeting of intestinalPrevotella copriby aListeria monocytogenesbacteriocin

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