volume 191, issue 8, P4399-4411 2013
DOI: 10.4049/jimmunol.1301858
View full text
Cheng Peng, Laurel A. Eckhardt

Abstract: We previously described a check-point for allelic exclusion that occurs at the pre-B to immature B cell transition and is dependent upon IgH intronic enhancer, Eμ. We now provide evidence that the breach in allelic exclusion associated with Eμ deletion results from decreased Igμ levels that make it difficult for emerging B cell receptors (BCRs) to reach the signaling threshold required for positive selection into the immature B cell compartment. We show that this compartment is smaller in mice carrying an Eμ-…

expand abstract