Role of the hematopoietic cytokines SCF, IL-3, GM-CSF and M-CSF in the diagnosis of pancreatic and ampullary cancer

Vasiliades, G.; Kopanakis, Nikolaos; Vasiloglou, Michalis; Zografos, George; Margaris, Helias; Masselou, Kyriaki; Kokosi, Evniki; Liakakos, Theodore

doi:10.5301/jbm.2012.9348

Cited by 21 publications

(22 citation statements)

References 30 publications

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“…Our observation is supported by data regarding M-CSF from a previous report by Ławicki et al [33] in breast cancer patients. They are also in line with the observations of other authors studying M-CSF levels in patients with pancreatic cancer [34]. Furthermore, it has observed that M-CSF concentrations are statistically different in every group (the analysis related to CC stage) compared to healthy subjects.…”

Section: Discussionsupporting

confidence: 91%

“…In the case of M-CSF, the specificity reported in the paper by Ławicki et al [37] on cervical cancer was marginally higher than that obtained in our study (92%). M-CSF specificity obtained by Vasiliades [34] et al in the study on pancreatic cancer was lower than ours (62.5%). This discrepancy is probably due to the differences in the types of cancers studied.…”

Section: Discussioncontrasting

confidence: 80%

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Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis

Lubowicka

Zbucka-Krętowska

Sidorkiewicz

et al. 2019

Pathol. Oncol. Res.

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Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-2 (MMP-2) and its specific tissue inhibitor (TIMP-2) may play an important role in the pathogenesis of cancer disease. We investigated the plasma levels and diagnostic power (ROC curve analysis) of M-CSF, MMP-2, TIMP-2 and tumor markers CA 125 and SCC-Ag in cervical cancer (CC) patients as compared to control group. The study included 89 patients with cervical cancer. The control group consisted of 50 healthy, untreated women. The plasma levels of M-CSF, MMP-2 and TIMP-2 were determined using ELISA, CA 125 and SCC-Agby CMIA method. The median levels of M-CSF, TIMP-2, SCC-Ag and CA 125 in the entire group of CC were significantly different than compared to the healthy women group. MMP-2 showed the highest value of sensitivity from all examined parameters (in stage I of CC -93.10%, II -82.76%, III and IV -96.88%, total group -92.05%). The highest specificity was obtained by M-CSF (86%). The area under the ROC curve (AUC) of M-CSF (0.8051) was the largest of all the tested parameters (even higher than commonly used tumor markers) in the group of cervical cancer. The combination of M-CSF, MMP-2 or TIMP-2 with SCC antigen resulted in an increase AUCs in all cases (0.8760;0.7880;0.8081;respectively). The findings of this study suggest the usefulness of all examined parameters in the diagnostics of CC patients. Out of the tested substances, M-CSF also appears to be the best candidate for cancer diagnostics in all stages of the disease, based on ROC analysis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 80%

Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis

Lubowicka

Zbucka-Krętowska

Sidorkiewicz

et al. 2019

Pathol. Oncol. Res.

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“…Moreover, IL-6 and its downstream pathways, such as the JAK/STAT pathway, have emerged as important factors in the modulation of cancerassociated inflammation [22]. The serum levels of GM-CSF in pancreatic patients showed a significant positive correlation with the serum levels of carcinoembryonic antigen (CEA), the most widely used pancreatic tumor marker [23]. In this study, we found that the percentages of IL-17A-, IL-6-, GM-CSF-producing cells decreased to varying degrees in splenocytes, mesenteric lymph node cells and tumor cells from embelin treated-mice (Fig.…”

Section: Discussionmentioning

confidence: 98%

Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells11These authors contributed equally to this work.

et al. 2014

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“…At this point it should be highlighted, that our cohort comprises 36 ampullary cancers, which is to our knowledge the largest ampullary carcinoma cohort analysed regarding CEA expression in literature thus far. There are many studies regarding CEA serum levels in patients as a tumor marker in different solid cancers 37, 38. In this context Kim et al found in their analyses of 104 ampullary cancers a multivariate significant influence of a CEA serum level > 5 ng/ml and disease recurrence.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study

Fuellgraf

Schilling²,

Lai

et al. 2017

J. Cancer

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Background: Carcinoembryonic antigen cell adhesion molecule (CEA) is a commonly immunohistochemically used antibody in pathological routine diagnostics with an overexpression in different cancers. We aimed to examine the immunohistochemically detectable CEA level in ampullary cancer and to correlate it with clinico-pathological data.Methods: Shot-gun proteomics revealed CEA in undifferentiated ampullary cancer cell lines. Next, tumor tissue of 40 ampullary cancers of a retrospective single center cohort of 40 patients was stained immunohistochemically for CEA; CEA expression was determined and correlated with clinico-pathological data.Results: Thirty-six patient specimens were included in statistical analysis. CEA expression and lymph node ratio (LNR) were the only independent predictors of overall survival in multivariate analysis.Conclusion: To our knowledge, cell line and patient cohorts are the largest and characterized cohorts examined for CEA so far. Hereby, CEA expression in ampullary cancer cells permits an estimation of outcome and suggests an opportunity for individualized CEA-directed therapy. Further trials with larger cohorts are needed to verify our results and to integrate CEA immunohistochemistry into clinical routine.

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Role of the hematopoietic cytokines SCF, IL-3, GM-CSF and M-CSF in the diagnosis of pancreatic and ampullary cancer

Abstract: The diagnostic ability of M-CSF and SCF in pancreatic and ampullary cancer should stimulate further studies evaluating their clinical usefulness as tumor markers.

Cited by 21 publications

References 30 publications

Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis

Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis

Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells11These authors contributed equally to this work.

The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study

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