Role of sun exposure on nevus. First study in age-sex phenotype-controlled populations

Multiple senile lentigos of the face, a skin ageing pattern resulting from a life excess of intermittent sun exposure in dark-skinned caucasians: a case-control study

“…When studying sun exposure as a risk factor for skin disorders, the role of ‘intermittent’ sun exposure is often contrasted with the role of ‘cumulative’ exposure. Melanoma 11 and basal cell carcinoma 12 are generally attributed to ‘intermittent’ sun exposure, without a clear cumulative effect, whereas wrinkles, 8–10 keratoses 13 and squamous cell carcinoma 14 are generally considered as linked to cumulative sun exposure, and naevi to both types of exposure 15 . Contrasting ‘intermittent’ with ‘cumulative’ is, however, an incorrect oversimplification.…”

The dysplastic nevus: From historical perspective to management in the modern era

“…A role for UV radiation in the development of nevi is somewhat controversial, with some studies showing no relationship between patterns of sun exposure and numbers of nevi in patients, 82 while others report significantly increased numbers of nevi on intermittently and chronically sun-exposed areas 83 and in children living in sunnier climates. 84 Most studies purporting to examine the role of UV in promoting the development of DN (compared to CN), however, are difficult to interpret since identification of DN was based on clinical examination alone.…”

“…84 Most studies purporting to examine the role of UV in promoting the development of DN (compared to CN), however, are difficult to interpret since identification of DN was based on clinical examination alone. 83–86 Stierner et al 87 found that patients with DNS had larger differences in nevus counts between sun-exposed and sun-protected areas than control subjects, suggesting heightened sensitivity to “nevogenic” effects of UV. This finding is consistent with studies showing that nevi in patients undergoing UVB phototherapy develop more irregular macroscopic and dermoscopic features over time, 88 but histologic correlates have not been described.…”

Longitudinal Assessment of the Nevus Phenotype in a Melanoma Kindred

“…Because nevus development has been associated with constitutional phenotype (light hair, eye color, Fitzpatrick skin type) (Green et al, 1995) as well as environmental factors, including acute (Richard et al, 1993;Bataille et al, 1998) and chronic sun exposure (Richard et al, 1993;Wachsmuth et al, 2001), we sought to determine if differences in these parameters could partially explain the dramatic phenotypic differences observed among the genotypic groups. Presence of red hair or light-colored eyes was not significantly associated with increased number of nevi at the initial or follow-up examination (red hair: p ¼ 0.17 for TNN at first visit; p ¼ 0.52 for TNN at follow-up; light eyes: p ¼ 0.42 at first visit; p ¼ 0.49 at follow-up, Mann-Whitney U test).…”