Role of steroid hormones and prolactin in canine mammary cancer

Queiroga, Felisbina L.; Alenza, María Dolores Pérez; Silván, Gema; Peña, Laura; Lopes, Carlos; Illera, Juan Carlos

doi:10.1016/j.jsbmb.2004.12.014

Cited by 59 publications

(84 citation statements)

References 36 publications

(41 reference statements)

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“…Moreover, some reports have shown that estrogens and synthetic progestins, which are commonly used in veterinary practice, seem to enhance tumor formation (Rutteman 1992;Selman et al, 1995;Stovring et al, 1997). Recently, it was observed that levels of steroid hormones in serum and tissue homogenates were higher in bitches with malignant mammary tumors (MMT) compared to benign mammary tumors (BMT), indicating that steroid hormones could act as local growth factors in the malignant types, stimulating their proliferation (Queiroga et al, 2005).…”

Section: Hormonal Factorsmentioning

confidence: 99%

“…Recently, some researchers have proposed that Prolactin (PRL) could have a role in canine mammary tumorigenesis. A study showed that bitches with mammary tumors have higher serum PRL levels than healthy ones, and PRL levels in mammary tissue are greater in MMT than in BMT or normal glands, suggesting that neoplastic mammary tissue could be a source of PRL (Queiroga et al, 2005). Moreover, Michel et al, (2012) observed that PRL receptor expression is lower in MMT than BMT, suggesting that the loss of this receptor may be a characteristic of tumor dedifferentiation.…”

Section: Hormonal Factorsmentioning

confidence: 99%

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Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

2016

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Mammary tumors are the most common neoplasm in the female dog, with a median age of appearance between 9 and 11 years. They may appear as single or multiple nodules, and posterior mammary glands are more frequently affected than anterior glands. Both benign and malignant tumors may occur in the dog, and according to histological criteria, approximately 50% of the tumors are malignant. Mammary gland tumors tend to be heterogeneous in their pathological characteristics and clinical behavior. Different hormones and growth factors play a key role in the development of this neoplasm, however, the mechanism by which they influence tumor growth and their possible prognostic value are still under study. Besides, new therapeutic options for each particular tumor type are being developed. The aim of this article is to review pathological, prognostic and therapeutic aspects of canine mammary neoplasms.

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Section: Hormonal Factorsmentioning

confidence: 99%

Section: Hormonal Factorsmentioning

confidence: 99%

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

2016

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“…Steroid hormones are important in mammary gland development, possibly in the formation of neoplastic tissue in mammary glands [5] . In the studies conducted in dogs serum E2, SO4E1, T [5,8,14] and P4 [5,8] levels were found higher (P<0.01) in CMTs when compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Mammary tumours are the most common type of tumour in female dogs, women and cats [1][2][3][4][5][6][7] . Mammary tumours mostly affect middle-aged and elderly bitches [4] , between the age 6 to 10 [3] , median age; 10 to 11 years [6] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Prolactin, Steroid Hormone Levels in Tissue Homogenate, Serum and Receptor Distributions in Canine Mammary Tumours

Enginler¹,

Toydemir²,

Ateş³

et al. 2014

Kafkas Univ Vet Fak Derg

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The aim of the present study is to determine variations of estrone sulphate (SO4E1), progesterone (P4), 17-beta estradiol (E2), testosterone (T) and prolactin (PRL) levels in serum, mammary tissue homogenates as well as variations in the distribution of androgen (AR), estrogen alpha (ERα), progesterone (PR) and prolactin (PRL-R) receptors in mammary tumours of dogs. Thirty bitches from different breeds and ages with mammary lesions (experiment group) and 10 healthy bitches (free of any mammary lesions=control group) were used in this study. All the dogs included to the study were in anoestrus. Mammary lesions of experiment group were surgically removed and 10 normal mammary tissue samples were collected by surgical biopsy from control group dogs. Fifty-seven mammary tissue samples were obtained and were divided into two fragments for histopathology/ immunohistochemistry and for hormone determinations in tissue homogenate. Besides, blood samples were collected from all dogs before the surgeries to detect hormonal variations. Student t-test was used for serum samples, one way ANOVA and tukey test were used in tissue homogenate for statistical analysis. According to current study results; PRL levels in serum were found significantly higher (P<0.01) in the experiment group compared to the control group. In tissue homogenate samples, T levels were found to be significantly (P<0.01) higher in malignant mammary tissue samples. PR was intensely expressed in 23, PRL-R was expressed in 13, ERα was expressed in 9 and AR was expressed in 6 cases of canine malignant mammary tumours (CMTs). In conclusion, PRL levels in serum, T in tissue can act on the formation of canine mammary tumours which may have different features of developments in different mammary glands of the same dog and with the predominance of PR expression in CMT. Keywords: Prolactin, Receptor distribution, Serum, Steroid hormone, Tissue homogenate Meme Tümörlü Köpeklerde Serumda, Doku Homojenatında Prolaktin ve Steroid Hormon Seviyeleri ile Reseptör Dağılımlarının Belirlenmesi ÖzetBu çalışmanın amacı östron sülfat (SO4E1), progesteron (P4), östradiol 17-beta (E2), testosteron (T) ve prolaktin (PRL) seviyeleri değişikliklerinin serumda ve doku homojenatında, androjen (AR), östrojen alfa (ERα), progesteron (PR) ve prolaktin (PRL-R) reseptör dağılım değişikliklerinin köpeklerde meme tümörlerinde saptanmasıdır. Değişik ırk ve yaşta meme lezyonlu otuz köpek (çalışma grubu) ve 10 sağlıklı köpek (herhangi bir meme lezyonu olmayan=kontrol grubu) çalışmada kullanıldı. Çalışmaya katılan tüm köpekler anöstrustaydı. Çalışma grubu köpeklerin meme lezyonları cerrahi olarak uzaklaştırıldı ve 10 normal meme dokusu örneği kontrol grubu köpeklerden cerrahi biyopsi ile toplandı. Elli-yedi meme dokusu örneği toplandı, histopatoloji/immunohistokimya ve doku homojenatında hormon değişikliklerinin saptanması için iki parçaya ayrıldı. Bunun dışında, tüm köpeklerden ameliyat öncesi kan örnekleri toplandı. Serum örnekleri için student t-test, one way ANOVA ve tukey testi de doku homoj...

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“…In female canines, mammary tumors are considered one of the most important cancers due to their high prevalence [4][5][6] and represent nearly 20% of all tumors in this species [7]. A new classification for this type of neoplasia in female canines was recently released and is very similar to that established for human females, with one important difference being the existence of complex tumors (with epithelial and myoepithelial components) in dogs.…”

Section: Introductionmentioning

confidence: 99%

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2017

Int J Pathol Clin Res

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Role of steroid hormones and prolactin in canine mammary cancer

Cited by 59 publications

References 36 publications

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

Assessment of Prolactin, Steroid Hormone Levels in Tissue Homogenate, Serum and Receptor Distributions in Canine Mammary Tumours

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