Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospects

Lv, Zeheng; Ding, Yan; Cao, Waixiang; Wang, Shuyun; Gao, Kun

doi:10.7150/ijbs.65457

Cited by 11 publications

(7 citation statements)

References 50 publications

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“…High expression of the RIPOR2 gene in hair follicle cells has been associated with the regulation of hair growth, which has been confirmed by the presence of polymorphisms that cause hair loss in humans [ 26 ]. Disorders in the RIPOR2 gene are also accompanied by the development of oncological diseases [ 27 ]. The effect of the gene on productivity in animals has not been studied, but the described effects of mutations in it allowed us to consider it as a potential candidate gene for further study.…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

Krivoruchko

Surov

Skokova

et al. 2022

Genes

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In a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes (MSTN, MEF2B, FABP4, etc.), a genome-wide search for associations of individual polymorphisms with intravital indicators of meat productivity was performed. Using the Ovine Infinium HD BeadChip 600K, 606,000 genome loci were evaluated. Twenty-three substitutions were found to be significantly associated with external measurements of the body and ultrasonic parameters. This made it possible to describe 14 candidate genes, the structural features of which can cause changes in animal phenotypes. No closely spaced genes were found for two substitutions. The identified polymorphisms were found in the exons, introns, and adjacent regions of the following genes and transcripts: CDCA2, ENSOARG00000014477, C4BPA, RIPOR2, ENSOARG00000007198, ENSOARG00000026965 (LincRNA), ENSOARG00000026436 (LincRNA), ENSOARG00000026782 (LincRNA), TENM3, RTL8A, MOSPD1, RTL8С, RIMS2, and P4HA3. The detected genes affect the metabolic pathways of cell differentiation and proliferation and are associated with the regulation of the immune system. This confirms their possible participation in the formation of the phenotypes of productivity parameters in animals and indicates the need for further study of the structure of candidate genes in order to identify their internal polymorphisms.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

Krivoruchko

Surov

Skokova

et al. 2022

Genes

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“…The robust expression of fam65c gene, a member of the Rho family-interacting cell polarization regulator (RIPORs), was probably linked to the migration of xanthophores/erythrophores. This gene plays an essential role in the modulation of the cell differentiation, migration, adhesion, polarization and organelle tra cking [39,40], apart from immunity [41]. Several common DEGs discovered in xanthophores/ erythrophores coloration in shes [18,42], such as the tgm, clbn, thbs and hoax, were also found in the RMAvsRMJ but their roles in pigmentation have remained unexplored.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals the differential genes associated with skin growth and pigmentation between Red Melon and Red Cover Discus

Danish-Daniel

Ng²,

Lau

et al. 2023

Preprint

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This is the first report to describe the differential growth of cutaneous pigments and the molecular processes involved in two red discus (Symphysodon spp.), Red Melon and Red Cover, with different tones of red pigmentation develop from juveniles to adults. Microscopic observation detected xanthophores in all samples, erythrophores in both adult groups and Red Melon juveniles, while melanophores were only found in Red Cover. The skin transcriptome analysis revealed extracellular matrix (ECM) activities and collagen metabolic genes were elevated in both juveniles, as compared to the adults. The development of erythrophores and xanthophores in the Red Melon juveniles were regulated by genes involved in the pteridine synthesis, one-carbon metabolism, and lipid metabolism. Temporal inhibition of melanophore development in Red Melon juveniles might be attributed to the active expression of Wnt-signalling inhibitor genes, sost and notum2. Melanosome transport in Red Cover was likely relied on microtubules and the spectrin-associated cytoskeleton. Tyrosinase late N-glycan processing and its transport from Golgi apparatus into the melanosome were differentially expressed in RC adults and juveniles.

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“…Actin reorganization is regulated by cofilin and LIMK, which are downstream molecules of RhoA, and their phosphorylation is regulated by RhoA activation [ 35 ]. The regulation between autophagy and the RHO family has double-planedness in some studies [ 36 , 37 ]. Herein, we found that both Siglec-15 silencing and Beclin-1 depletion could decrease RhoA activation and lessen the formation of lamellipodial protrusions in the submembranous area in osteosarcoma cells.…”

Section: Discussionmentioning

confidence: 99%

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

et al. 2022

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Background Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in osteosarcoma patients. However, the effect of Siglec-15 on autophagy in osteosarcoma remains unclear, while the role and mechanism of Siglec-15-related autophagy in lung metastasis also remain unknown. Methods The expression levels of Siglec-15 and Beclin-1 were detected in osteosarcoma tissues using immunohistochemistry (IHC). The effect of Siglec-15 on metastasis was investigated using Transwell, wound healing and animal experiments with osteosarcoma cells. Corresponding proteins were confirmed using Western blotting when Siglec-15 or Beclin-1 was silenced or overexpressed. Changes in autophagy and the cytoskeleton were detected using immunofluorescence and transmission electron microscopy. Results Siglec-15 and Beclin-1 expression was evaluated both in lung metastases and in patients who presented with pulmonary metastasis of osteosarcoma. Immunoprecipitation experiments revealed that Siglec-15 interacts directly with Beclin-1, an important autophagic protein. Moreover, loss of Siglec-15 distinctly inhibited autophagy and reduced Beclin-1/ATG14 expression. The decreased invasion and migration caused by Siglec-15 silencing could be reversed by Beclin-1 overexpression. Additionally, autophagy can promote the epithelial–mesenchymal transition (EMT) and affect cytoskeletal rearrangement, which was confirmed by overexpression or silencing of Beclin-1. Conclusions These findings confirmed the role of Siglec-15 in the regulation of autophagy and elaborated the relationship and mechanisms between autophagy and the metastasis of osteosarcoma cells.

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Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospects

Cited by 11 publications

References 50 publications

A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

Transcriptomic analysis reveals the differential genes associated with skin growth and pigmentation between Red Melon and Red Cover Discus

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

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