Role of redoximiRs in fibrogenesis

Fierro-Fernández, Marta; Miguel, Verónica; Lamas, Santiago

doi:10.1016/j.redox.2015.11.006

Cited by 36 publications

(25 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs are also able to regulate the expression of genes controlling the generation of ROS, known to contribute to fibrotic accumulation. Therefore, therapeutic approaches targeting miRNAs involved in regulating redox balance involved in fibrosis may represent a novel strategy for drug development [ 204 ]. Understanding how coenzyme Q10 (CoQ10) supplementation can help diabetic patients reveals low glutaredoxin-1 levels after treatment [ 205 ].…”

Section: Antioxidant Approach By Natural Agents: the Road To Detecmentioning

confidence: 99%

The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System

Angelini

Pagano

Bordin

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions. When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental. Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeostasis. Current advances in our understanding of epigenetics have revealed a parallel scenario showing the influence of oxidative stress as a major regulator of epigenetic gene regulation via modification of DNA methylation, histones, and microRNAs. This has provided both the biological link and a potential molecular explanation between oxidative stress and cardiovascular/metabolic phenomena. Accordingly, in this review, we will provide current insights on the physiological and pathological impact of changes in oxidative states on cardiovascular disorders, by specifically focusing on the influence of epigenetic regulation. A special emphasis will highlight the effect on epigenetic regulation of human's current life habits, external and environmental factors, including food intake, tobacco, air pollution, and antioxidant-based approaches. Additionally, the strategy to quantify oxidative states in humans in order to determine which biological marker could best match a subject's profile will be discussed.

show abstract

Section: Antioxidant Approach By Natural Agents: the Road To Detecmentioning

confidence: 99%

The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System

Angelini

Pagano

Bordin

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…[15][16][17] In the kidney, miRNAs are not only indispensable for development and homeostasis, but also they are important players in pathophysiology. Their role in the progression and establishment of organ fibrosis has been reviewed elsewhere.…”

Section: Introductionmentioning

confidence: 99%

MiR‐9‐5p protects from kidney fibrosis by metabolic reprogramming

et al. 2019

Self Cite

View full text Add to dashboard Cite

MicroRNAs (miRNAs) regulate gene expression posttranscriptionally and controlbiological processes (BPs), including fibrogenesis. Kidney fibrosis remains a clinical challenge and miRNAs may represent a valid therapeutic avenue. We show that miR-9-5p protected from renal fibrosis in the mouse model of unilateral ureteral obstruction (UUO). This was reflected in reduced expression of pro-fibrotic markers, decreased number of infiltrating monocytes/macrophages, and diminished tubular epithelial cell injury and transforming growth factor-beta 1 (TGF-β1)-dependent dedifferentiation in human kidney proximal tubular (HKC-8) cells. RNA-sequencing (RNA-Seq) studies in the UUO model revealed that treatment with miR-9-5p prevented the downregulation of genes related to key metabolic pathways, including mitochondrial function, oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO), and glycolysis. Studies in human tubular epithelial cells demonstrated that miR-9-5p impeded TGF-β1-induced bioenergetics derangement. The expression of the FAO-related axis peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)-peroxisome proliferator-activated receptor alpha (PPARα) was reduced by UUO, although preserved by the administration of miR-9-5p. We found that in mice null for the mitochondrial master regulator PGC-1α, miR-9-5p was unable to promote a protective effect in the UUO model. We propose that miR-9-5p elicits a protective response to chronic kidney injury and renal fibrosis by inducing | 411 FIERRO-FERNÁNDEZ Et al.

show abstract

“…52,53 The hepatic antioxidant systems are controlled by epigenetic mechanisms such as changes in microRNAs expression pattern. 54,55 MicroRNAs have more recently been identified to control oxidative stress in liver and related diseases. 14 Excessive ROS production in cancer cell exerts a control on the microRNA processing machinery and transcription factors of microRNA genes that affect microRNAs expression level, such as those involved in the control of the cellular redox homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Formula derived Maillard reaction products in post-weaning intrauterine growth-restricted piglets induce developmental programming of hepatic oxidative stress independently of microRNA-21 and microRNA-155

Firmin¹,

Elmhiri²,

Crépin³

et al. 2018

J Dev Orig Health Dis

View full text Add to dashboard Cite

We recently reported augmentation of lipid peroxidation products in the liver of intrauterine growth-restricted (IUGR) piglets fed a high load of Maillard reaction products (MRPs) during suckling period. The underlying mechanisms of MRPs effects remain unknown. Here, we studied the long-term impact of MRPs exposure on liver oxidative status of IUGR juvenile pigs. Livers of 54-day-old pigs suckled with formula containing either a high (HHF, n=8) or a low (LHF: n=8) load of MRPs were analyzed for protein carbonylation levels , activities and messenger RNA (mRNA) expression of glutathione (GSH) and main antioxidant regulators of redox homeostasis [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured. In addition, mRNA levels of miRNA-21 and miRNA-155 were measured. The liver of HHF group exhibited a high level of lipid peroxidation with significantly increased expression and activity of SOD. Further in liver of HHF group, CAT activity was decreased as compared with LHF group, though with comparable total protein carbonyl contents, GSH contents, and expression of GPx and microRNAs (miRNA-21 and miRNA-155). Our findings suggest that the potential mechanism of MRPs-mediated oxidative stress programming in liver of IUGR piglets may occur via impairment of antioxidant defenses.

show abstract

Role of redoximiRs in fibrogenesis

Cited by 36 publications

References 189 publications

The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System

The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System

MiR‐9‐5p protects from kidney fibrosis by metabolic reprogramming

Formula derived Maillard reaction products in post-weaning intrauterine growth-restricted piglets induce developmental programming of hepatic oxidative stress independently of microRNA-21 and microRNA-155

Contact Info

Product

Resources

About