Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion

Sevillano, Julio; Sánchez, María del Mar; Pizarro-Delgado, Javier; Ramos-Álvarez, María del Pilar

doi:10.3390/ijms22115812

Cited by 21 publications

(9 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that inhibition of PTP1B, a main negative regulator of insulin receptor signaling, can improve glucose homeostasis and insulin signaling ( 131 ). In the insulin receptor signaling cascade, protein tyrosine kinase amplifies the insulin signaling response, and phosphatase is necessary to regulate the rate and duration of the reaction ( 132 ).…”

Section: The Mechanism Of Irmentioning

confidence: 99%

The crucial role and mechanism of insulin resistance in metabolic disease

Xin

Yang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.

show abstract

Section: The Mechanism Of Irmentioning

confidence: 99%

The crucial role and mechanism of insulin resistance in metabolic disease

Xin

Yang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Protein tyrosine phosphorylation plays an important role in signal transduction processes involved in cell growth, metabolism, differentiation, and survival [ 1 ]. Protein tyrosine phosphatases (PTPs) along with protein tyrosine kinases control the phosphorylation of tyrosine residues [ 2 ]. PTPs serve as important regulators of signaling events and regulate tyrosine phosphorylation by catalyzing the removal of phosphate groups from phosphorylated tyrosine residues in proteins [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Terminalin from African Mango (Irvingia gabonensis) Stimulates Glucose Uptake through Inhibition of Protein Tyrosine Phosphatases

et al. 2022

View full text Add to dashboard Cite

Protein tyrosine phosphatases (PTPs), along with protein tyrosine kinases, control signaling pathways involved in cell growth, metabolism, differentiation, proliferation, and survival. Several PTPs, such as PTPN1, PTPN2, PTPN9, PTPN11, PTPRS, and DUSP9, disrupt insulin signaling and trigger type 2 diabetes, indicating that PTPs are promising drug targets for the treatment or prevention of type 2 diabetes. As part of an ongoing study on the discovery of pharmacologically active bioactive natural products, we conducted a phytochemical investigation of African mango (Irvingia gabonensis) using liquid chromatography–mass spectrometry (LC/MS)-based analysis, which led to the isolation of terminalin as a major component from the extract of the seeds of I. gabonensis. The structure of terminalin was characterized by spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high-resolution (HR) electrospray ionization (ESI) mass spectroscopy. Moreover, terminalin was evaluated for its antidiabetic property; terminalin inhibited the catalytic activity of PTPN1, PTPN9, PTPN11, and PTPRS in vitro and led to a significant increase in glucose uptake in differentiated C2C12 muscle cells, indicating that terminalin exhibits antidiabetic effect through the PTP inhibitory mechanism. These findings suggest that terminalin derived from African mango could be used as a functional food ingredient or pharmaceutical supplement for the prevention of type 2 diabetes.

show abstract

“…Insulin, a negative regulator of its own signal transduction, downregulates the cell surface receptor when the insulin level increases, which contributes to reduced insulin signal transduction (Haeusler et al, 2018). In vitro studies have found that inhibition of serine/threonine phosphorylation can antagonize or terminate insulin signaling and thus is an important mechanism of IR (Sevillano et al, 2021). In addition, inflammatory cytokines and lipotoxicity can also inhibit phosphorylation (Kalafati et al, 2021;Lyu et al, 2021).…”

Section: Ir and Pcos Endometriummentioning

confidence: 99%

Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium

Zhang

Feng

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

As a highly dynamic tissue, the endometrium is periodically shed in response to the secretion of estrogen and progesterone. After menarche, the endometrium of healthy women proliferates and differentiates under the action of steroid hormones (e.g., 17β-estradiol and progesterone) that are secreted by the ovaries to provide appropriate conditions for embryo implantation. Polycystic ovary syndrome (PCOS), a prevalent endocrine and metabolic disorder in reproductive-aged women, is usually associated with multiple cysts within the ovaries and excess levels of androgen and is characterized by hirsutism, acne, menstrual irregularity, infertility, and increased risk of insulin resistance. Multiple factors, such as anovulation, endocrine-metabolic abnormalities, and inflammation, can disrupt the endometrium in PCOS patients and can lead to endometrial hyperplasia, pregnancy complications, or even cancer. Despite many recent studies, the relationship between PCOS and abnormal endometrial function is still not fully understood. In this review, we investigate the correlation of PCOS patient endometrium with anovulation, hyperandrogenemia, insulin resistance, progesterone resistance, and inflammatory cytokines, aiming to provide a theoretical basis for the treatment of disorders caused by endometrial dysfunction in PCOS patients.

show abstract

Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion

Cited by 21 publications

References 68 publications

The crucial role and mechanism of insulin resistance in metabolic disease

The crucial role and mechanism of insulin resistance in metabolic disease

Terminalin from African Mango (Irvingia gabonensis) Stimulates Glucose Uptake through Inhibition of Protein Tyrosine Phosphatases

Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium

Contact Info

Product

Resources

About