Role of Postradiation Genome Instability in Evaluating the Development of Radiation-Determined Pathology in Children after the Chernobyl Accidentand Investigation Perspectives

Abstract

The role of genetic instability (inferred from cytogenetic parameters of chromosome aberrations) and nuclear DNA repair activity play in radiation-determined diseases (neoplasms, including malignancies; congenital disorders and malformations; and chromosomal disorders) is considered in children from regions varying in extent of soil contamination with cesium-137 after the Chernobyl Accident.