AbstractImatinib targets Bcr-Abl, the causative event of chronic myelogenous leukemia (CML), and addresses leukemic cells to growth arrest and cell death. The exact mechanisms responsible for imatinib-induced cell death are still unclear. We investigated the role of poly(ADP-ribose) polymerase (PARP) activity in imatinib-induced cell death in Bcr-Ablpositive cells. Imatinib leads to a rapid increase of poly(ADPribosyl)ation (PAR) preceding loss of integrity of mitochondrial membrane and DNA fragmentation. The…
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