2011
DOI: 10.1002/iub.521
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Abstract: SummaryNeuronal differentiation is characterized by neuritogenesis and neurite outgrowth, processes, which are critically dependent on membrane biosynthesis, and therefore, on the expression and regulation of enzymes involved in phospholipid biosynthesis. During the last decade a great effort was made to clarify where membrane lipids are synthesized, how the newly synthesized membrane components reach the membrane and are inserted during neuritogenesis and to elucidate the mechanism by which the supply of new … Show more

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Cited by 46 publications
(58 citation statements)
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“…It is a precursor to the neurotransmitter acetylcholine and choline deficiency has been linked to neurological impairment [51]. Choline’s direct oxidation product is betaine, which plays important roles in cell volume regulation, cell stability, and the regulation and detoxification of homocysteine [52].…”
Section: Microbiota Produced Metabolites and The Evolving Relationshimentioning
confidence: 99%
“…It is a precursor to the neurotransmitter acetylcholine and choline deficiency has been linked to neurological impairment [51]. Choline’s direct oxidation product is betaine, which plays important roles in cell volume regulation, cell stability, and the regulation and detoxification of homocysteine [52].…”
Section: Microbiota Produced Metabolites and The Evolving Relationshimentioning
confidence: 99%
“…The PEMT gene encodes for an enzyme synthesizing membrane phospholipids associated with SZ (74). This gene helps mediate Arachidonic acid signaling, neuronal differentiation and neurite growth (75). The GPC6 gene belongs to the glypicans that promote glutamate receptor clustering, receptivity and induce postsynaptic synapse formation (76).…”
Section: G9mentioning
confidence: 99%
“…Animal model studies reveal adequate levels of choline are required for appropriate formation of phospholipid membranes and the neurotransmitter acetylcholine, with choline deficiency, producing neurological impairment (2). The direct oxidation product of choline is betaine, which is a methyl donor in homocysteine remethylation, and also plays an important role in maintaining cellular volume and stability (3).…”
Section: Introductionmentioning
confidence: 99%