2018
DOI: 10.15761/ohns.1000193
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Abstract: Objective: Nasal polyps are, benign growths outgrowths of sinonasal tissue, affecting approximately 1-4% of the population. They have been correlated to the presence of chronic inflammation, but the molecular underlying mechanisms has not been completely defined. Defective epithelial barrier has been correlated with chronic rhinosinusitis (CRS) and nasal polyps (NPs) Moreover, a variation of ΔNp63 isoform expression has been noted in human airway epithelial cells and in the NPs epithelium. The benign lesion in… Show more

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Cited by 2 publications
(2 citation statements)
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References 52 publications
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“…Some studies found that p63-positive basal cells were significantly increased in CRS [28] and NPs [26], while the expression of the tight junctions and adhesion molecules between the epithelial cells were downregulated [9,29]. In addition, the higher expression of p63 was considered to be associated with postoperative recurrence of NPs [30]. Although the expression of p63 is related to a variety of biological functions in airway epithelium, a few downstream pathways regulated by p63 have been found, such as AP-1 [31], and GATA-6 [32], and the downstream molecular mechanisms related to p63 are still unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies found that p63-positive basal cells were significantly increased in CRS [28] and NPs [26], while the expression of the tight junctions and adhesion molecules between the epithelial cells were downregulated [9,29]. In addition, the higher expression of p63 was considered to be associated with postoperative recurrence of NPs [30]. Although the expression of p63 is related to a variety of biological functions in airway epithelium, a few downstream pathways regulated by p63 have been found, such as AP-1 [31], and GATA-6 [32], and the downstream molecular mechanisms related to p63 are still unclear.…”
Section: Discussionmentioning
confidence: 99%
“…These TAp63null mice are also highly tumor prone and develop metastatic diseases [11,14], reaffirming the tumor suppressor functions of TAp63 proteins. Data from Ernesto Bruno group suggest that TAp63 suppresses recurrence of nasal polyps [15]. According to reports from group of Esther H. Chang, miR-130b and TAp63 form a feed-forward loop, and this miR-130b/ TAp63 axis is a druggable pathway that has the potential to uncover broad-spectrum therapeutic options for the majority of p53-altered cancers [16].…”
mentioning
confidence: 99%