volume 7, issue 1, P70-81 2015
DOI: 10.18632/aging.100722
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Zongsong Wu, Yi Yu, Chang Liu, Yuyan Xiong, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Ming

Abstract: p38 mitogen-activated protein kinase (p38) regulates cellular senescence and senescence-associated secretory phenotype (SASP), i.e., secretion of cytokines and/or chemokines. Previous work showed that augmented arginase-II (Arg-II) and S6K1 interact with each other to promote endothelial senescence through uncoupling of endothelial nitric oxide synthase (eNOS). Here we demonstrate eNOS-uncoupling, augmented expression/secretion of IL-6 and IL-8, elevation of p38 activation and Arg-II levels in senescent endoth…

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