Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

Kirpatovskiy, V.I.; Plotnikov, Egor Y.; Mudraya, I. S.; Голованов, С.А.; Дрожжева, В. В.; Khromov, R. A.; Chernikov, D. Y.; Vp, Skulachev; Zorov, Dmitry B.

doi:10.1134/s0006297913050131

Cited by 12 publications

(19 citation statements)

References 25 publications

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“…Oxidative stress is characterized by both acute and chronic episodes and it causes an increase in reactive oxygen species. Certain vital cell components, such as proteins, lipids and nucleic acids, and consequently organs are affected and their functions are impaired (13). In our study, TOS levels in bladder tissue were significantly higher than the control group on the first day according to TAC levels.…”

Section: Discussionmentioning

confidence: 40%

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Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

Öğüş

Ayyıldız

Keseroğlu

et al. 2020

Revista Romana De Medicina De Laborator

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Background: The aim of this study is to determine the changes of some oxidative stress parameters following an experimental urethral injury.Materials and Methods: 24 Wistar-Albino male rats were used and 18 of them were exposed to urethral injury. Total oxidant status (TOS) and total antioxidant capacity (TAC) values in bladder and penile tissues and sera of rats during creation and healing stages of injury (control, day-1, 7 and 21) were examined and evaluated histopathologically.Results: TOS levels in both tissue and serum groups increased nearly 4x fold in first day following injury. On the seventh day, TOS levels of bladder and penile tissue showed a nearly 50% decrease according to first day (p=0.005; p=0.025, respectively). At the end of third week, while bladder TOS levels decreased to control values, penile tissue TOS levels remained at high levels. The bladder TAC values mildly increased in first day (p=0.026) and then returned to normal levels in seventh day and continued to decrease down by half of control levels at the end of third week (p=0.005). TAC levels of penile tissue increased twofold in first day (p=0.021) and remained at same high levels for three weeks.Conclusion: We observed that first day after traumatic urethral injury seems to be very important for evaluation of traumatic injuries and wound healing. We believe when an urethral injury was occured, both urethra and bladder should be handled with care and without delay during urethral healing, because of the presence of oxidative changes in bladder.

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Section: Discussionmentioning

confidence: 40%

“…After the urethral injury, it is possible to develop only dysuria and urethral pain, and acute urinary retention may also occur due to the degree and severity of injury. Acute urinary retention is associated with bladder ischemia (13). Often an urethral catheter is used to cure this condition.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

Öğüş

Ayyıldız

Keseroğlu

et al. 2020

Revista Romana De Medicina De Laborator

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“…Brain trauma, brain ischemia, and Alzheimer's disease promote excessive production of free radicals in the brain. As shown previously by our group, extremely low, nanomolar concentrations of mitochondria-targeted antioxidants of the SkQ family are effective in preventing negative effects in animal models of these pathologies (Bakeeva et al, 2008;Plotnikov et al, 2010;Kapay et al, 2011;Isaev et al, 2012;Silachev et al, 2012;Kirpatovsky et al, 2013;Genrikhs et al, 2015).…”

Section: Introductionmentioning

confidence: 68%

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type

Isaev

Stelmashook

Генрихс

et al. 2016

Reviews in the Neurosciences

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AbstractIn 2008, using a model of compression brain ischemia, we presented the first evidence that mitochondria-targeted antioxidants of the SkQ family, i.e. SkQR1 [10-(6′-plastoquinonyl)decylrhodamine], have a neuroprotective action. It was shown that intraperitoneal injections of SkQR1 (0.5–1 μmol/kg) 1 day before ischemia significantly decreased the damaged brain area. Later, we studied in more detail the anti-ischemic action of this antioxidant in a model of experimental focal ischemia provoked by unilateral intravascular occlusion of the middle cerebral artery. The neuroprotective action of SkQ family compounds (SkQR1, SkQ1, SkQTR1, SkQT1) was manifested through the decrease in trauma-induced neurological deficit in animals and prevention of amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices. At present, most neurophysiologists suppose that long-term potentiation underlies cellular mechanisms of memory and learning. They consider inhibition of this process by amyloid-β1-42 as an in vitro model of memory disturbance in Alzheimer’s disease. Further development of the above studies revealed that mitochondria-targeted antioxidants could retard accumulation of hyperphosphorylated τ-protein, as well as amyloid-β1-42, and its precursor APP in the brain, which are involved in developing neurodegenerative processes in Alzheimer’s disease.

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“…While these changes do not impact contractility directly, they can lead to AcB through high pressure over‐distention injury due to lack of sensation. Distention in turn leads ischaemia and oxidative stress, with subsequent myogenic changes as described below . The most common causes of such afferent pathway injuries include diabetic neuropathy and pernicious anaemia.…”

Section: Pathophysiologymentioning

confidence: 99%

Current concepts of the acontractile bladder

et al. 2018

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The acontractile bladder (AcB) is a urodynamic-based diagnosis wherein the bladder is unable to demonstrate any contraction during a pressure flow study. Although it is often grouped with underactive bladder, it is a unique phenomenon and should be investigated independently. The purpose of the present review was to examine the current literature on AcB regarding its pathology, diagnosis, current management guidelines, and future developments. We performed a review of the PubMed database, classifying the evidence for AcB pathology, diagnosis, treatment, and potential future treatments. Over the 67 years covered in our review period, 42 studies were identified that met our criteria. Studies were largely poor quality and mainly consisted of retrospective review or animal models. The underlying pathology of AcB is variable with both neurological and myogenic aetiologies. Treatment is largely tailored for renal preservation and reduction of infection. Although future developments may allow more functional restorative treatments, current treatments mainly focus on bladder drainage. AcB is a unique and understudied bladder phenomenon. Treatment is largely based on symptoms and presentation. While cellular therapy and neuromodulation may hold promise, further research is needed into the underlying neuro-urological pathophysiology of this disease so that we may better develop future treatments.

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Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

Cited by 12 publications

References 25 publications

Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type

Current concepts of the acontractile bladder

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