Role of Optical Coherence Tomography Angiography in Detecting and Monitoring Inflammatory Choroidal Neovascularization

Kongwattananon, Wijak; Grašić, David Josip; Lin, Henry J.; Oyeniran, Enny; Sen, H. Nida; Kodati, Shilpa

doi:10.1097/iae.0000000000003420

Cited by 10 publications

(3 citation statements)

References 31 publications

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“…En face OCT, which is widely used in retinal and choroidal diseases (Gallo et al, 2022;Kongwattananon et al, 2022), has been used to visualize vasculatures. Recent advancements in hardware and software have facilitated the incorporation of posterior segment OCT technologies into anterior segment OCT systems, enabling imaging that is free from motion artifacts and providing enhanced resolution and depth penetration.…”

Section: Discussionmentioning

confidence: 99%

En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma

Huang,

Tian,

Sun

et al. 2023

Front. Physiol.

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Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction.Methods: In this Prospective comparative study, we included 100 eyes from 50 patients diagnosed with POAG and 50 healthy controls. Three-dimensional cube and line scans of the temporal and nasal quadrants of the anterior segment of the limbus were acquired using SS-OCT. SC was identified using en face and cross-sectional images. The diameter and area of SC in cross-sectional images and the visible percentage and area of SC in en face images were measured using ImageJ.Results: SC was observed in 84% of en face images and 81% of cross-sectional images in eyes with POAG but in 92% of en face images and 86% of cross-sectional images in control eyes. Significant differences between the POAG and normal control eyes were found in the en face area (0.35 ± 0.14 mm2 vs. 0.56 ± 0.22 mm2 in the temporal quadrant and 0.36 ± 0.14 mm2 vs. 0.58 ± 0.23 mm2 in the nasal quadrant; both p < 0.001) and visible percentage of SC (85.71% vs. 94.91% and 87.10% vs. 95.52% in the temporal and nasal quadrant respectively, both p < 0.001) in en face images as well as the cross-sectional area (2790.9 ± 942.2 μm2 vs. 4138.6 ± 2027.8 μm2 in the temporal quadrant and 2805.7 ± 947.2 μm2 vs. 4224.0 ± 2002.2 μm2 in the nasal quadrant, both p < 0.001) and diameter of SC (123.1 ± 25.4 μm vs. 149.5 ± 34.7 μm in the temporal quadrant and 126.3 ± 28.9 μm vs. 155.3 ± 36.0 μm in the nasal quadrant, both p < 0.001) in cross-section images. In addition, the mean intraocular pressure (IOP) significantly correlated with the en face area, visible percentage of SC, and cross-sectional area in the temporal and nasal quadrants.Conclusion: SS-OCT can obtain high-quality en face images of SC without post-acquisition processing. Eyes with POAG had a decreased en face SC area compared with normal eyes. A correlation between SC area, visible percentage of en face images, and IOP was also observed.

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Section: Discussionmentioning

confidence: 99%

En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma

Huang,

Tian,

Sun

et al. 2023

Front. Physiol.

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“…OCT-A was shown to be useful and a help in the detection of choroidal neovascularization (CNV) such as in MFC/PIC and other choriocapillaritis entities as well as its followup during anti-VEGF treatment but none of the articles recommended it as an exclusive use. [29][30][31][32][33][34] One report indicated that OCT-A could possibly better identify new vessels obscured by retinal haemorrhage [35]. OCT-A has been reported to be useful to distinguish CNV from active uveitic lesions [36].…”

Section: Optical Coherence Tomography Angiography (Oct-a)mentioning

confidence: 99%

Review on imaging methods in non-infectious posterior uveitis, principles, relevance, and practical clinical applications to disease entities

Papasavvas

Herbort

2023

Oftalmol Zh

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The work-up and diagnosis of posterior uveitis rely heavily on multiple imaging methods that have become available beyond the mere photographic imaging and fluorescein angiography (FA) used to image uveitis in the past. Global assessment and precise follow-up of posterior uveitis were achieved with the development of indocyanine green angiography (ICGA) since the mid-1990ties that, together with FA, made it possible to perform dual FA and ICGA giving information on both the retina and the choroidal compartment. Further non-invasive imaging methods were developed subsequently that contributed to additional valuable information completing the dual FA/ICGA basic appraisal of uveitis, including (1) optical coherence tomography (OCT) giving a quasi-histological morphology of retinal structures of the posterior pole, (2) enhanced-depth imaging OCT (EDI-OCT) allowing to image the choroidal compartment and (3) blue light fundus autofluorescence (BAF) showing the integrity or damage of the retinal pigment epithelium, the photoreceptors and the outer retina. OCT-angiography (OCT-A) became available more recently and presented the advantage to image the retinal and choroidal circulations without needing dye injections, necessary for dual FA/ICGA. This review article will illustrate the principles, relevance and practical applications of these different imaging methods used in uveitis by examining the main categories of non-infectious posterior uveitis entities including (1) retinal inflammatory disorders, inflammatory diseases of the outer retina and of the choriocapillaris (choriocapillaritis) and stromal choroiditis.

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“…Spectral-domain (SD) OCTA and swept-source (SS) OCTA have been found useful to study inflammatory chorioretinal diseases [ 3 , 4 , 5 , 6 , 7 , 8 ]. For example, inflammatory chorio retinal neovascularization (iCNV) can be imaged with OCTA, as it yields high-resolution images of abnormal vasculature [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

OCT Angiography in Noninfectious Uveitis: A Description of Five Cases and Clinical Applications

et al. 2023

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Background: Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality used to analyze the retinochoroidal vasculature and detect vascular flow. The resulting images can be segmented to view each vascular plexus individually. While fluorescein angiography is still the gold standard for the diagnosis of posterior uveitis, it has limitations, and can be replaced by OCTA in some cases. Methods: This case series describes five patients with posterior noninfectious uveitis and their description by OCTA. Results: Cases included lupus retinopathy (n = 1) for which OCTA showed ischemic maculopathy as areas of flow deficit at the superficial and deep capillary plexus; choroidal granulomas (n = 1) with a non-detectable flow signal in the choroid; active punctate inner choroiditis and multifocal choroiditis (n = 1) with OCTA that showed active inflammatory chorioretinal lesions as non-detectable flow signals in choriocapillaris and choroid; dense type 2 inflammatory secondary neovascularization (n = 1) associated with active choroiditis; and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) (n = 1) without flow abnormalities at the superficial and deep retinal plexuses but non-detectable flow at the levels of the choriocapillaris and choroid. Conclusions: Ophthalmologists can use OCTA to identify inflammatory changes in retinal and choroidal vasculature, aiding in the diagnosis, management, and monitoring of posterior uveitis.

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Role of Optical Coherence Tomography Angiography in Detecting and Monitoring Inflammatory Choroidal Neovascularization

Cited by 10 publications

References 31 publications

En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma

En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma

Review on imaging methods in non-infectious posterior uveitis, principles, relevance, and practical clinical applications to disease entities

OCT Angiography in Noninfectious Uveitis: A Description of Five Cases and Clinical Applications

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