Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex

Jayakumar, Arumugam R.; Sujatha, Rani; Paul, Vanaja; Asokan, C. V.; Govindasamy, S.; Rajadas, Jayakumar

doi:10.1016/s0006-8993(99)01692-3

Cited by 41 publications

(33 citation statements)

References 29 publications

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“…Convulsion latency: Latency was measured as the time between injection of PTZ and appearance of the first clonic convulsion, which was indicated by a sudden twitching of head or jerky movement of body (Jayakumar et al, 1999).…”

Section: Ptz-induced Seizuresmentioning

confidence: 99%

Erythropoietin prevents the increase in blood–brain barrier permeability during pentylentetrazol induced seizures

et al. 2006

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Section: Ptz-induced Seizuresmentioning

confidence: 99%

Erythropoietin prevents the increase in blood–brain barrier permeability during pentylentetrazol induced seizures

et al. 2006

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“…This effect could not be explained by nonspecific change since only L-arginine but not the biologically inactive enantiomer, D-arginine modified this parameter. On the other hand, the literature shows contradictory results regarding the dose-response relationship between L-arginine and NO production (Buchmann et al, 1996;Jayakumar et al, 1999). The dose of L-arginine what we used, has been found to produce NO in cerebral cortex of rats while half of this dose did not (Paul and Jayakumar, 2000).…”

Section: Discussionmentioning

confidence: 72%

Nitrergic, glutamatergic and gabaergic systems in lithium toxicity

et al. 2012

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-We examined the role of nitrergic, glutamatergic and gamma-aminobutyric acid (GABA)-ergic systems in the mechanism(s) underlying lithium induced acute toxicity. With this aim, lithium (18 mEq/kg, i.p.) intoxicated rats were observed for 3 hr recording their clinical signs and death. Lithium exposure at the dose used produced central nervous system (CNS) depression. Pre-treatment of N w -nitro-L-arginine methyl ester (L-NAME) a nonselective nitric oxide synthase inhibitor (10 mg/kg, i.p.), 7-nitroindazole (7-NI) a selective neuronal nitric oxide synthase inhibitor (25 mg/kg, i.p.), nitric oxide precursor L-arginine (1,000 mg/kg, i.p.) and MK-801 a noncompetitive antagonist of N-methyl-D-aspartic acid class of glutamate receptors (0.5 mg/kg, i.p.) all increased CNS depression and mortality in lithium group however, no change was seen in GABA receptor agonist GABA (1,000 mg/kg, i.p.) or D-arginine (1,000 mg/kg, i.p.) a biologically inactive enantiomer of L-arginine pre-treated rats. Glutamic acid decarboxylase (GAD) enzyme activity was measured in hippocampus, cerebral cortex and cerebellum of the different groups of animals. GAD enzyme activity reduced in cerebral cortex but not altered in hippocampus or cerebellum by lithium as compared to the control (saline) group. We conclude that an interaction with nitrergic and glutamatergic systems may have a role in the acute toxicity of lithium in rats.The inhibition of glutamate metabolism may arise from this interaction and the involvement of GABA-ergic system should be further investigated in this toxicity.

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“…The GABA is biosynthesized by glutamate decarboxylase (GAD) and is degraded by GABA transaminase (GABA-T). 15) Because the GABA concentration were increased with the glutamate concentration in a dose dependent manner (data not shown), it was assumed that the anaerobic treatment for enhancing the GABA concentration resulted from the potentiation of the GAD activity rather than by the inhibition of GABA-T. A further study will be needed to evaluate the GAD and GABA-T assay to determine the precise mechanism for the increasing GABA content. ML and GAML did not increase the neurite outgrowth activities in the PC12 cells.…”

Section: Discussionmentioning

confidence: 98%

Enhancement of Neuroprotection of Mulberry Leaves (Morus alba L.) Prepared by the Anaerobic Treatment against Ischemic Damage

Kang

Jung

et al. 2006

Biological & Pharmaceutical Bulletin

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Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex

Cited by 41 publications

References 29 publications

Erythropoietin prevents the increase in blood–brain barrier permeability during pentylentetrazol induced seizures

Erythropoietin prevents the increase in blood–brain barrier permeability during pentylentetrazol induced seizures

Nitrergic, glutamatergic and gabaergic systems in lithium toxicity

Enhancement of Neuroprotection of Mulberry Leaves (Morus alba L.) Prepared by the Anaerobic Treatment against Ischemic Damage

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