2008
DOI: 10.1590/s0004-28032008000200013
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Abstract: -Background -Hepatic cirrhosis is the final stage of liver dysfunction, characterized by diffuse fibrosis which is the main response to the liver injury. The inhalatory carbon tetrachloride is an effective experimental model that triggers cirrhosis and allows to obtain histological and physiological modifications similar to the one seen in humans. Aim -To investigate the effects of N-acetylcysteine (NAC) on the fibrosis and oxidative stress in the liver of cirrhotic rats, analyzing liver function tests, lipope… Show more

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Cited by 55 publications
(21 citation statements)
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References 37 publications
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“…When the liver lesion parameters (AST and ALT) were analyzed, only the NAC-treated group presented a reduction in the AST plasma levels compared to the septic group, demonstrating its hepatoprotective role. This protective ability has been previously described in the literature, using carbon tetrachloride (CCl 4 )-induced cirrhotic animals, suggesting a protective effect related to the glutathione peroxidase, an endogenous antioxidant enzyme key in combating the ROS [49]. To verify that NAC would increase the cellular antioxidant defenses, we have also measured hepatic reduced glutathione levels.…”
Section: Discussionsupporting
confidence: 56%
“…Oxidative stress plays an important role in the activation of hepatic stellate cells. Antioxidants such as albumin, can prevent this activation and their subsequent role in liver fibrogenesis 7 . Studies show that there is a decrease in plasma levels of albumin in rats with common bile duct ligation, although they have conflicting results 8,9 , with two weeks of the beginning of the experiments, probably due to increased capillary permeability and a lack of compensation by increasing its hepatic synthesis, to a decrease of the same, and also by an increase in plasma volume after four weeks of the beginning of the experiment 10 .…”
Section: Introductionmentioning
confidence: 99%
“…Ko et al, 1995 reported that certain natural extracts containing antioxidants protect against the CCl4-induced increased lipid peroxide levels and impairment in hepatic GSH status.Hepatic malondialdehyde (MDA) levels were also highly significantly increased in CCl4 treated group, showing an increased oxidative stress compared to control group. The increased MDA level suggests enhanced lipid peroxidation leading to tissue damage and failure of antioxidant defense mechanisms to prevent formation of excessive free radicals as described by (Pereira- Filho et al, 2008) and confirmed by (Kim et al, 2010).…”
Section: Discussionmentioning
confidence: 55%
“…Many experimental studies are also available using NAC on ROS-mediated hepatotoxicity induced by CCl 4 [10,11,24] , as it is the case in the present study. Experimental evidence indicates NAC is able to enhance the intracellular biosynthesis of GSH [9][10][11][12]24] , and therefore NAC increases GSH levels and replenish GSH store [8] .…”
Section: Discussionmentioning
confidence: 91%
“…NAC exerts its antioxidant action by facilitating reduced glutathione biosynthesis and scavenging the reactive oxygen species formed during oxidative stress [18]. Many are the reports of beneficial effects of NAC such as renoprotective [19], antiangiogenic [20], anticancer [21], hepatoprotective [22], antifibrotic [23], as chelating agent in metal poisoning treatment [24], and as neuroprotective [25]. However, few are the reports about NAC direct effects on cerebral AChE activity.…”
Section: Introductionmentioning
confidence: 99%