2014
DOI: 10.18632/aging.100685
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Abstract: Vascular aging is accompanied by increases in circulatory proinflammatory cytokines leading to inflammatory endothelial response implicated in early atherogenesis. To study the possible role of mitochondria-derived reactive oxygen species (ROS) in this phenomenon, we applied the effective mitochondria-targeted antioxidant SkQ1, the conjugate of plastoquinone with dodecyltriphenylphosphonium. Eight months treatment of (CBAxC57BL/6) F1 mice with SkQ1 did not prevent age-related elevation of the major proinflamma… Show more

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Cited by 53 publications
(68 citation statements)
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References 82 publications
(98 reference statements)
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“…A statistically significant reduction in wound area compared to the control was detected on the 4th and 7th days. Histological analysis on the 14 th day of the experiment showed that in the wounds that were closed by this time, the animals receiving SkQ1 contained thicker bundles of collagen fibers than in the control that presumably caused by an increased activity of myofibroblasts [54].…”
Section: Local Administration Of Skq1 Accelerates Reparative Processementioning
confidence: 93%
“…Counting the number of neutrophils in the early stages of wound healing showed a more than twofold decrease in the number of neutrophils after 7 hours in SkQ1 treated rats. In the maturation phase of the granulation tissue, SkQ1 caused a 3-fold increase in the number of myofibroblasts expressing smooth-muscle beta-actin [54].…”
Section: Local Administration Of Skq1 Accelerates Reparative Processementioning
confidence: 99%
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