2005
DOI: 10.1007/s00280-005-0047-y View full text |Buy / Rent full text
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Abstract: TBMS1 opens the permeability transition (PT) pore, thereby decreasing Deltapsim, releasing Cyt c from mitochondria, and further causing a series of events consistent with established mechanistic models of apoptosis.

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“…It was recently reported that mitochondrial dysfunction is essential to the apoptotic pathway, and loss of ΔΨm may be an early event in the apoptotic process [22] . Reduced ΔΨm induces cytochrome C release from the mitochondria, and causes apoptosis [23][24][25] . In this study, 0.5 and 1 mmol/L of PE significantly decreased the ΔΨm (Figure 2C-E), suggesting that PE induces apoptosis of HepG2 cells via the mitochondrial pathway.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…It was recently reported that mitochondrial dysfunction is essential to the apoptotic pathway, and loss of ΔΨm may be an early event in the apoptotic process [22] . Reduced ΔΨm induces cytochrome C release from the mitochondria, and causes apoptosis [23][24][25] . In this study, 0.5 and 1 mmol/L of PE significantly decreased the ΔΨm (Figure 2C-E), suggesting that PE induces apoptosis of HepG2 cells via the mitochondrial pathway.…”
Section: Discussionmentioning
“…Although TBMS I has been shown to inhibit proliferation of several types of tumor cell in vitro by promoting apoptotic processes 19) and endocytoplasmic reticulum stress 22) in the cell, it has not been evaluated, to our best knowledge, for its anti-tumor effect on hepatoma cells. Here, we instead studied the in vitro cytotoxic effects of TBMS I on either cancerous or normal cells of the same type, and demonstrated that at least to TBMS I, the cancerous cells were more sensitive as compared to their normal counterparts.…”
Section: Discussionmentioning
“…Briefly, cells were prepared similarly as above but on 20 mm diameter coverslips, and then treated with either sham or 20 mM TBMS I for 24 h before staining with Hoechst 33258, or 3 h before staining with Tubulin-Tracker Red. 19) Subsequent to the treatment of sham or TBMS I, cells were washed in PBS and fixed with 4% paraformaldehyde for 10 min. For nucleus staining, the fixed cells were incubated with Hoechst 33258 fluorescent dye (5 mg/ml) for 10 min, and then washed and dried before use.…”
Section: Methodsmentioning
“…These studies suggest that TBMS I is be a candidate novel antitumor drug, despite its side effects on the digestive system causing nausea and vomiting (6). Furthermore, at the molecular level, the TBMS I-induced growth inhibition of cancer cells may well be mediated through apoptosis-associated processes, including microtubule depolymerization (7), prolonged endoplasmic reticulum stress (8) and mitochondrial dysfunction, which leads to decreased expression of anti-apoptotic proteins, increased expression of pro-apoptotic proteins and release of cytochrome c (8,9).…”
Section: Introductionmentioning