Role of medicinal plants against Alzheimer’s disease

Abstract

Alzheimer's is an irreversible and dynamic neurodegenerative ailment which associated with the age and characterized by serious loss of memory, personality changes, uncommon behaviour and decrease in intellectual capacity. Till now no countermeasure available for Alzheimer's, however symptomatic treatment may enhance memory and other issues related to this disease. Products from natural resources such as medicinal plants have been utilized for the treatment of various memory disorders like amnesia, dementia, Alzheimer's, Parkinson since long time. Various studies depicted the utilization of therapeutic plants for treatment of Alzheimer's. In spite of that exact mode of their action is yet indistinct. Phytochemical investigations of various plant parts have demonstrated presence of numerous bioactive compounds, such as polyphenols, tannins, flavonoids, triterpenes, alkaloids and sterols. These compounds demonstrate an extensive variety of pharmacological activities which includes anticholinesterase, antiinflammatory, antiamyloidogenic, hypolipidemic, and antioxidant effects. This review provides the description of different medicinal plants against Alzheimer's disease.

Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives

“…Furthermore, neuronal cell death caused by amyloid plaques was blocked by withanamide. Molecular modeling studies have shown that withanamide A and C attach uniquely to the active beta-amyloid pattern (Aβ 25–35) and block fibril formation [ 7 , 151 ].…”

“…Accordingly, these findings indicate that W. somnifera extracts, especially WA, reduce oxidative stress and mitochondrial dysfunction, and their beneficial role appears to be primarily based on their antioxidant properties [ 6 ]. Withanamides are a subset of these components that have been proven to scavenge free radicals produced at the time of the initiation and progression of AD [ 7 , 151 ].…”

“…Within this context, WA exhibited beneficial properties for the prevention of AD. WA has an important role in AD by reversing the reduction in cholinergic markers such as choline acetyltransferase (ChAT) and acetylcholine [ 28 , 150 , 151 ]. In an in vitro assay, the AChE and BuChE enzyme activity was blocked by WA [ 21 ].…”

An updated review on Anti-Alzheimer’s herbal drugs

“…Herbal therapy for AD has more advantages when compared to currently existing drug therapies with unavoidable side effects .it can also improve the patients' quality of life as they can be consumed as Nutraceuticals and even any slight increase in dose may not be a problem when consumed. In order to deliver these herbal formulations a proper route of administration must be selected so that they reach the site and show the therapeutic action Huperzia serrata [10,11,28,29] Lycopoidaceae 22,28,[30][31][32] .…”

Therapeutic potential of Zingiberaceae in Alzheimer's disease

“…Most species of this Family are aromatic, presenting perineal with or without tuberous rhizomes, and most of them have medicinal properties (Larsen et al, 1998;Saensouk et al, 2016). Popularly, these plants are widely used as food, seasoning, and for the treatment of a wide range of diseases due to their antimicrobial, antioxidant (Chen et al, 2008), anti-inflammatory (Namsa et al, 2009), analgesic, nematicidal, vasorelaxant, sedative, antineoplastic, anti-allergic, healing (Umar et al, 2011), antitussive, anti-influenza, antiemetic, antidiarrheal, antidiabetic, anti-urinary incontinence activities (Kumar et al, 2011;Victório, 2011), and widely studied regarding its AD pharmacological effects (Monroy et al, 2013;Roy, 2018).…”