Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats

Prabhu, S.; Jainu, Mallika; Sabitha, Kuruvimalai Ekambaram; Devi, C. S. Shyamala

doi:10.1016/j.jep.2006.02.014

Cited by 96 publications

(51 citation statements)

References 38 publications

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“…These studies indicate that one of the mechanisms through which mangiferin affords antioxidant effects is through quenching of reactive oxygen intermediates. In addition, the effects of mangiferin on other oxidation pathways leading to an antioxidant effect have also been reported (Dar et al 2005;Pardo-Andreu et al 2008a, b;Prabhu et al 2006;Rodeiro et al 2008).…”

Section: Mangiferinmentioning

confidence: 73%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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Nutraceuticals from natural sources have been investigated for their putative chemopreventive and cancer therapeutic properties for the last few decades. The interest in these compounds is in part due to their pleiotropic effects and relatively non-toxic nature. A large number of such nutraceuticals are under detailed investigations worldwide but most of them suffer from the lack of sufficient bioavailability in humans. The identification and characterization of novel natural compounds with sufficient anticancer potential is therefore an ongoing process. This article is a summary of anticancer activity of three such novel nutraceuticals, namely garcinol, plumbagin and mangiferin. These compounds have shown promising biological activity in preliminary studies by targeting multiple signaling pathways. In particular, it seems that the inhibition of NF-κB pathway is one of the major mechanism through which these compounds exhibit their anticancer and apoptosis-inducing effects. The data on their anticancer activity is just emerging and the information on their bioavailability is still insufficient to predict their future application in the clinical settings. In this article, we have surveyed the available literature to summarize the mechanisms of anticancer activity of these three novel nutraceuticals. We also discuss the challenges and possible solutions to realize the dream on the translational potential of these compounds into clinical practice for the prevention and/or treatment of human malignancies.

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Section: Mangiferinmentioning

confidence: 73%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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“…Vitamin E is a major lipid soluble non-enzymatic antioxidant present in cell membranes and lipoproteins that protects against oxidative modification in the body [23] . The observed decrease in the Vitamin E level, in the present study, might be due to increased utilization for the neutralization of ISO mediated free radicals and lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Upaganlawar

Vaibhav

Balaraman

2012

Asian Pacific Journal of Tropical Biomedicine

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“…With respect to toxicity, a study with rats showed that the level of mangiferin required to trigger myocardial infarction is above 1000 mg·kg −1 per day [37]. In this study, the mangiferin levels are low, indicating that the tea could be consumed without producing toxic effects.…”

Section: Mangiferin Concentration In Teasmentioning

confidence: 57%

Extraction of Mangiferin and Chemical Characterization and Sensorial Analysis of Teas from Mangifera indica L. Leaves of the Ubá Variety

et al. 2016

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Abstract:Mangiferin is present in various parts of Mangifera indica L. and has proven biological activities, such as antioxidant capabilities. The aim of this work was to evaluate the chemical composition of teas prepared from M. indica leaves, their potential use as a source of mangiferin and their total phenolic compounds. Teas were prepared with young and mature leaves of M. indica at three (medicinal plant: solvent) ratios utilizing three different preparation techniques. The mangiferin content was analyzed via high-performance liquid chromatography (HPLC). The tea with the highest mangiferin content was characterized for its total phenolic content and antioxidant activity. The oxidative stability was also evaluated by quantifying mangiferin, total phenolics and antioxidant activity using two preservation treatments for 0, 24 and 48 h. Sensory analysis was performed to measure the acceptance of the tea. The type of leaf, preparation technique and concentration influenced the mangiferin content in the teas. The highest concentration of mangiferin was obtained through decoction at a 5% (w/v) medicinal plant concentration. This tea exhibited stability up to 48 h after preparation under both preservation treatments and provided a positive sensory acceptance for consumers with flavors added. In conclusion, teas made from M. indica leaves have great potential as sources of mangiferin and phenolic compounds.

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Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats

Cited by 96 publications

References 38 publications

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

Extraction of Mangiferin and Chemical Characterization and Sensorial Analysis of Teas from Mangifera indica L. Leaves of the Ubá Variety

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