Role of ischemia in the induction of changes in cell membrane during hemorrhagic shock

Metabolic responses in feline “red” and “white” skeletal muscle to shock and ischemia

“…These electrolyte disturbances have repeatedly been shown to be reflected in a decrease in the resting membrane potential of skeletal muscle during shock (e.g. Carnpion et al 1969;b, Trunkey et al 1973, Jennische et al 1978a) as well as during total ischemia (Arango et al 1976, Enger et al 1978. The reason for these changes in the membrane function during hypoxia is not known.…”

Membrane Defect and Energy Status of Rabbit Skeletal Muscle Cells in Sepsis and Septic Shock

“…However, in all of the animals, the PD was lower than 75 Biopsy specimens for ATP and CP content determina¬ tions were obtained during the last hour of shock (mean, 18.3 minutes before death) at the time of profound depo¬ larization of skeletal muscle cell membranes (mean, 61.1 ± 3.1 mV) and a mean systolic BP of 55.5 ± 13.6 mm Hg. The resulting data, compared with the normal values determined in the control period, are given in the Table. The content of ATP and CP was expressed as micromoles per gram of wet tissue and nanomoles per milligram of protein to avoid distortion of the results secondary to the cellular uptake of water during shock.…”