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“…Highdose PPI therapy was more effective in reducing the volume of blood transfusion compared with ordinary-dose of PPI therapy [11]. There was no significant difference between intravenous and oral PPI therapy.…”
Section: Non-endoscopic Therapymentioning
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“…Highdose PPI therapy was more effective in reducing the volume of blood transfusion compared with ordinary-dose of PPI therapy [11]. There was no significant difference between intravenous and oral PPI therapy.…”
Section: Non-endoscopic Therapymentioning
“…A systematic meta-analysis, based on published controlled data in the medical literature, reported no benefit of neoadjuvant (pre-endoscopic) PPI therapy on rates of rebleeding, salvage surgery for failures of endoscopic hemostasis, or mortality [17] . Adjuvant PPI therapy, administered following diagnostic and/or therapeutic EGD, has been proven effective, as well, leading to a decrease in recurrent PUD bleeding, need for blood transfusion, need for surgery, and duration of hospital stay [3,18,19] . Despite these major impacts, studies have not demonstrated an impact of PPIs on mortality due to UGIH [3,20,21] .…”
Section: Pharmacologic Therapy Prior To Endoscopymentioning
“…However, a subgroup analysis revealed that patients with actively spurting ulcer bleeds treated with pantoprazole had fewer adverse clinical outcomes than did ranitidine. Finally, a study by Lin et al [51] compared intravenous administration of omeprazole, 40 mg every 6 hours; omeprazole, 40 mg every 12 hours; and cimetidine, 400 mg every 12 hours in patients who had successful endoscopic injection hemostasis therapy for ulcer bleeding. The group receiving omeprazole every 6 hours had fewer rebleeding events and required fewer blood transfusions than the cimetidine group.…”
Section: Low-or Intermediate-risk Stigmatamentioning